Analysis of high risk factors for chromosomal aberrations in peripheral blood lymphocytes of 200 radiation workers in Hainan Province
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 7
Abstract
ObjectiveTo investigate the current status and high-risk factors of chromosomal aberrations in peripheral blood lymphocytes ï¼PBLï¼ of radiation workers in Hainan Province.MethodsA total of 200 radiological workers who underwent occupational health examination in Hainan Provincial Hospital of Traditional Chinese Medicine from January 2021 to December 2021 were selected to collect the occupational health examination data and the rate of PBL chromosomal aberrations. The influencing factors of PBL chromosomal aberrations were analyzed by logistic regression model. The predictive value of logistic regression prediction model on PBL chromosomal aberrations were determined by using the reciver operator characteristic ï¼ROCï¼ curve.ResultsA total of 20 000 cells ï¼100 cells/personï¼ were tested. The chromosomal aberration rate was 0.37% ï¼74/20 000ï¼ and the PBL chromosomal aberration rate in the subjects was 6.00% ï¼12/200ï¼. Univariate analysis showed that PBL chromosomal aberrations in radiological workers were related to ageï¼ length of serviceï¼ type of work and education ï¼all P<0.05ï¼ï¼ but not to gender ï¼P>0.05ï¼. The logistic regression prediction model was constructed based on the influencing factorsï¼ with Ï2=9.413ï¼ df=9ï¼ P=0.852ï¼ suggesting a good model fit. The logistic regression prediction model predicted the area under the curve ï¼AUCï¼ for the occurrence of PBL chromosomal aberrations in radiation workers was 0.914 ï¼95%CIï¼ 0.866â0.949ï¼ï¼ with a cut-off value of 3.05ï¼ corresponding to a prediction sensitivity and specificity of 100.00% and 75.98%ï¼ respectively.ConclusionThe incidence of PBL chromosomal aberrations in radiological workers in Hainan Province was 6.00%ï¼ with ageï¼ working age and job type as high-risk factors and education level as a protective factor. The prediction model constructed by the above factors can provide a reliable basis for clinical prediction of PBL chromosomal aberrations in radiological workers.
Authors and Affiliations
ZHANG Yuhong,GU Yong,WU Qingshan,GAN Xiaofang,LIN Li,ZHANG Zhuangu,
Keywords
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