Analysis of Metabolic Syndrome in females with Polycystic Ovarian Syndrome
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 10
Abstract
Backgrounds: The metabolic syndrome (MBS) is a cluster of cardiovascular risk factors associated with excess of fat. The MBS is more common among women in PCOS than in normal women particularly in those with hyperinsulinemia and obesity. Objectives: To determine the prevalence of metabolic syndrome and its main determinants in women with PCOS. Methods: Hundred women, 50 with polycystic ovarian syndrome (PCOS) and 50 ages matched normal women served as a control. A prospective observational study was conducted in the age groups of 17-40 years in the gynaecological OPD in two tertiary centres from July 2016 to June 2017. Sociodemographic data, waist circumference (WC), height, weight, BMI and blood pressure were recorded. A fasting blood sample was obtained for serum glucose and lipid profile determination. For assessment of the metabolic syndrome (MBS) in the study groups, the NCEP ATPIII guideline was used. Results: The prevalence of MBS was 40% (20/50) in PCOS, 4 fold higher than that reported for women in the control group. Thirteen patients (57%) belonged to 26-40 years and 7 (26%) in 17-25 years. Waist circumference ≥ 88 cm and BP(≥ 130/85 mm of Hg) were found among 52% and 40% of patients with PCOS respectively in comparison to 18% and 10% of control women respectively(P=0.001).The study showed significant rise in triglyceride(≥ 150 mg/dl), HDL-cholesterol (< 50 mg/dl) and fasting insulin (≥25µIU/ml)levels. The main menstrual disorders associated with PCOS was oligomenorrhea, observed in 92% of women compared to 12% in control women (P=0.001). Hirsutism was found among 62% of PCOS women in comparison to 4% of control (P =0.001).Multiple logistic regression analysis shows that BMI (OR=2.053; 95% CI: 1.349-3.123; Wald statistics 11.284; P=0.001) and age (OR = 0.858; 95% CI: 0.703 -1.048; Wald statistics 2.256; P=0.133) are the associated factors for MBS among PCOS patients. Conclusion: The prevalence of metabolic syndrome in PCOS is high. Age above 25 years and waist circumference >88 cm with elevated BMI were powerful predictors of metabolic syndrome amongst PCOS women.
Authors and Affiliations
Dr Rupali Modak, Dr Gopal Chandra Mondal, Dr Amitava Pal, Dr Tapan Kumar Mondal
Keywords
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