Analysis of monitoring results of novel coronavirus IgM and IgG antibody levels in apheresis platelets donors and impact on blood safety
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 9
Abstract
Objective To monitor the positive rates of IgM and IgG antibodies and the changes in S/CO values over time in voluntary blood donors infected with SARS-CoV-2 after recovery, in order to provide theoretical basis and data support for ensuring clinical blood safety. Methods A total of 54 platelet donors who met the inclusion criteria were selected for this study, and 359 blood samples (plasma) from T1 to T7 (at 7 time points, spanning 14 to 15 weeks) were continuously monitored for SARS-CoV-2 IgM and IgG antibodies using fully automated chemi-luminescence method. Results Among 359 blood samples (plasma) from 54 donors, 349 were with valid test results.Eleven donors were tested positive for IgM, with a positive rate of 20.37%, and IgM antibody S/CO value gradually increased during T1-T3, but gradually decreased during T4-T7. Fifty-four donors were tested positive for IgG, with the positive rate of 100%, and the S/CO value of IgG antibody gradually decreased over time. During the period of T1 -T7, there was no significant difference in SARS-CoV-2 IgG antibody S/CO value between gender (male/female) or age group (18-39 years old /40-60 years old). Conclusion The positive rate of SARS-CoV-2 IgG antibody in platelet donors after recovery from SARS-CoV-2 infection was 100% during 2-14 weeks, and the IgG S/CO value gradually decreases over time. The long-term dynamic changes of SARS-CoV-2 serologically specific IgG and IgM antibodies in blood donors are worthy of further study.
Authors and Affiliations
Hui ZHANG, Xinwei WANG, Ruru HE, Zhenxing WEI, Jinheng LIANG, Dong PANG, Limin CHEN
Keywords
Related Articles
- EP ID EP738630
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.09.003
- Views 9
- Downloads 0
Analysis of guiding value and effect of TEG in clinical application of cryoprecipitation
Objective To retrospectively analyze the guiding significance and effect of thromboelogram (TEG) in the clinical use of cryoprecipitation. Methods A total of 289 patients with fibrinogen reduction, admitted to our hospit...
Investigation on the incidence and risk factors of fetomaternal hemorrhage syndrome in pregnant women in Changsha
Objective To investigate the incidence and possible risk factors of FMH among pregnant women in Changsha. Methods A total of pregnant women (6~42 weeks of gestation) who underwent prenatal examinations in our hospital fr...
Effect of storage temperature and time on coagulation factor after cryoprecipitated antihemophilic factor melting
Objective To study and compare the effects of different storage temperature and time on coagulation factor after cryoprecipitated antihemophilic factor(CAF) melting, and to provide reference for the establishment of indu...
Performance verification of domestic nucleic acid testing system in blood stations based on T/CSBT
Objective To explore the performance verification of the Shengxiang automatic NAT system for HBV DNA, HCV RNA and HIV RNA-1 using PCR-fluorescence in the laboratories of blood stations, in order to meet the requirements...
Model of "One Core, Multiple Elements" emergency blood donation volunteer team: a case study of Nanjing city
Objective To explore the model of "One Core, Multiple Elements" emergency blood donation volunteer team (referred to as the Model) . Methods The Nanjing City Voluntary Blood Donation Joint Meeting serves as the core, wit...