Analysis of non small cell lung carcinoma according to 2015 WHO classification and assess its prognostic and therapeutic implication in our study population
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Lung cancer is the leading cause of cancer related mortality worldwide. The precise diagnosis and subclassification based on small biopsies have direct impact on patient management and prognosis. The 2015 WHO classification of lung Tumors has been published with important changes from the 2004 WHO classification. It includes use of immunohistochemistry, emphasis on genetic studies and new classification for small biopsies and cytology similar to that proposed in the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Objective: To classify lung cancer based on 2015 WHO classification of lung tumour and to assess its therapeutic and prognostic implications in our study population. Materials and methods: A Retrospective analysis of small biopsy proven specimens of lung cancer were analysed based on Morphology, Special stains and IHC. Results: Based on morphology, NSCLC constitutes majority 82.5% of cases, among which SCC constitutes 59.2%, adenocarcinoma constitutes 25.82% and NSCLC-NOS constitutes 19.8%. With the use of special stains (Alcian blue/PAS) and the IHC markers (p40 and TTF 1), the percentage of NSCLC – NOS was minimised from 26% to 1.32%.Conclusion: The Classification based on WHO 2015 Classification of lung cancer is superior in terms of diagnostic, therapeutic and prognostic implications. Subtyping of NSCC-NOS using special stains and IHC markers is found extremely useful as diagnosis favouring adenocarcinoma have various therapeutic options.
Authors and Affiliations
I. Nithya M. D, R. Manoranjani M. D.
Keywords
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- EP ID EP451630
- DOI 10.9790/0853-1801030113.
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