Analysis of PAX5 expression of Hodgkin’s and non-Hodgkin’s lymphomas: in comparison with routine panel
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2016, Vol 1, Issue 1
Abstract
Aim of the study: To assess the expression of PAX5 in different types and stages of lymphomas and to study its utility in comparison with the classical pan B and T cell markers. Materials and Methods: Immunohistochemistry was done to detect the expression of PAX5, CD45, CD3, CD20, CD15 and CD30 in all cases of lymphoma reported for a period of two years. Results: 59 cases were reported as malignant lymphomas giving an overall incidence of 6.3% in our hospital. The age group ranged from 3 years to 75 years with a male preponderance. Nineteen cases were excluded owing to inadequate tissue samples. Of the 40 cases, 28 were nodal and 12 extra-nodal lymphomas. 33 cases were non-Hodgkin’s lymphoma and 7 were Hodgkin’s lymphoma. 23 out of the 40 cases were positive for PAX5 and out of 21 cases of B cell non-Hodgkin’s lymphoma, 18 were positive. Reed-Sternberg cells of Hodgkin’s lymphoma were positive in 5 cases. PAX5 was positive in most of the B cell nonHodgkin’s lymphoma and Hodgkin’s lymphoma regardless of the stage, age, sex and site. PAX5 was negative in all T cell nonHodgkin’s lymphoma and the cases of unclassified category. Conclusions: This study suggests that B cell neoplasms and Reed Stenberg cells strongly expressed PAX5 in comparison to classical lymphoma panel and hence can be a useful marker. However a larger prospective study on PAX 5 expression in Hodgkin’s Lymphoma is vital to look for an increased expression in subset of Indian population.
Authors and Affiliations
Priya Subashchandrabose, Lakshmikanth Ramiah Madanagopaal, Shanthakumari Sivanandam
Keywords
Related Articles
- EP ID EP232670
- DOI -
- Views 113
- Downloads 0
Clinicopathological evaluation of Benign Breast diseases- A Retrospective study in a medical college teaching hospital in Mandya
Background: Benign breast diseases are a neglected entity in developing countries despite the fact that they constitute the majority of breast complaints. Background knowledge of general features of individual breast dis...
Prospective study of Meningioma & diagnostic validity of MIB-1 index in grading of meningioma
Background: Meningioma is one of indolent neoplasm. Meningiomas may make their appearance in childhood or adolescence, but most are encountered in middle or later adult life. Females are affected more commonly than males...
Neumann’s Tumor Vs Abrikossoff’s Tumor: Uncommon Neoplasm with Controversial Histiogenesis (Granular Cell Tumor)
Granular cell tumor is an uncommon soft tissue tumor with controversial histiogenesis that can affect any organ of the body including orofacial region. It is mostly benign neoplasm. Neumann’s tumor and Abrikossoff’s tumo...
A study of cytological evaluation of pleural effusion
Effusions are extremely common and constitute a significant proportion of all cytologic specimens being examined in any laboratory of a general hospital1 Fluid analysis plays an important role in clinical medicine The ma...
Utility of cervical pap smears in screening of postmenopausal women
Introduction Cervical cancer is one of the most preventable and curable cancer The papanicolaou cervical cytology test is capable of detecting cervical cancer at an early stage and is widely used in developed countries w...