Analysis of Serum Zinc, Protein and Albumin Levels in Psoriasis: A Case Control Study
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
Psoriasis is a common, chronic, T-cell–mediated inflammatory disease of the skin which has both environmental and genetic components to its etiology. Psoriatic lesions are characterised by hyperproliferation of epidermal keratinocytes and hyperkeratosis, with resultant typical thickening and exfoliation of the erythematous skin .Exfoliation leads to loss of several nutrients from body resulting in deficiency states. So this study is undertaken to have an insight regarding the status of nutrients like zinc, protein and albumin levels in the serum of psoriatic patients. Serum zinc, protein and albumin levels are estimated in 50 newly diagnosed cases of psoriasis not on systemic regime for psoriasis or any other disease and in 50 age and sex matched controls. Descriptive and inferential statistical analysis were performed using SPSS version 17.0. Serum zinc levels are significantly lowered in patients with psoriasis compared to healthy subjects (p<0.05). In the present study, there is also significantly decreased levels of serum Total protein, albumin levels (p<0.05) and reversal of Albumin to Globulin ratio. Loss of protein and zinc through exfoliation and their increased requirement due to altered metabolism suggests adequate supplementation of proteins and zinc to improve the nutritional status and to prevent the complications.
Authors and Affiliations
Srividya. Adapa
Keywords
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