Analysis of Survival Data: Challenges and AlgorithmBased Model Selection
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 6
Abstract
Survival data is a special form of time to event data that is often encountered while modelling risk. The classical Cox proportional hazard model, that is popularly used to analyse survival data, cannot be used for modelling risk when the proportional hazard assumption is violated or when there is recurrent time to event data. In this context we conducted this narrative review to develop an algorithm for selection of advanced methods of analysing survival data in the above-mentioned situations. Findings were synthesized from literature retrieved from searches of Pubmed, Embase, and Google Scholar. Existing literature suggest that for non-proportionality, especially due to categorical predictors stratified Cox model may be useful. An accelerated failure time model is applicable in case of different follow-up time among different experimental groups and the median time to event is the outcome of interest instead of hazard. Extended Cox models and marginal models are used in case of multivariate ordered failure events and the type of model depends upon the presence of clustering and nature of ordering. In the presence of heterogeneity, a shared frailty model is used that is analogous to mixed models. More advanced models, including competing risk and multistate models are required for modelling competing risk, multiple states and multiple transitions. Joint models are used for multiple time dependent outcomes with different attributes. We have developed an algorithm based on the review for appropriate model selection to curb the challenge of modeling survival data and the algorithm is expected to help the naïve researchers in analysing survival data.
Authors and Affiliations
Kaushik Sarkar, Ranadip Chowdhury, Aparajita Dasgupta
Keywords
Related Articles
- EP ID EP348551
- DOI 10.7860/JCDR/2017/21903.10019
- Views 78
- Downloads 0
Correspondence: Knowledge Attitude and Perception of Sex Education among School Going Adolescents in Ambala District, Haryana, India: A Cross-Sectional Study
Letter to Editor
Comparative Evaluation of Platelet Rich Fibrin and Dehydrated Amniotic Membrane for the Treatment of Gingival Recession- A Clinical Study
Introduction: The main objective of any therapeutic intervention aimed at root coverage is to restore the tissue margin to the cemento-enamel junction and to regenerate the lost periodontium. Aim: To compare the effectiv...
A Prospective Analysis of Drug Interactions in Patients of Intensive Cardiac Care Unit
Introduction: Drug-Drug Interaction (DDI) is a serious concern in cardiac patients due to polypharmacy. Aim: The present study was aimed to identify the potential DDI among hospitalized cardiac patients and evaluate the...
Massive Pyonephrosis Presenting as a Mammoth Tumour in Pregnancy: A Case Report
ABSTRACT The overall incidence of ovarian tumours in pregnancy is 2.4-5.7% and because of the asymptomatic nature of ovarian mass it is usually diagnosed in late pregnancy when there may be symptoms produced by it. Due t...
Histopathological Analysis of Psoriasis in a Study of 24 Cases
ABSTRACT Introduction: As for any other organ system, diagnosis of skin disease involves history and examination. An instant diagnosis can be arrived upon by virtue of visibility of the skin taking into account various v...