ANALYSIS OF THE EFFECT OF LEVODOPA ON NEUROTRANSMITTERS USING QUANTITY METHOD
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 1
Abstract
The Benefit of the Levodopa or L-Dopa (LEV) to reduce the symptoms of Parkinson’s disease and have been studied and presented a concern for promoting the acceleration of neurodegeneration. The objective of the study is to determine, using the parametric semiempirical quantum method 3 (SE-PM3), that neurotransmitter (NT) has a higher affinity with LEV through Hyperchem professional software; it is possible to perform molecular models and analysis of the LEV and the nine primary NT. The result of the simulations of the quantum sediments reveals that Serotonin is the primary NT oxidized by the presence of LEV, correlating with multiple pathologies linked to the side effects of that drug.
Authors and Affiliations
Dr. Manuel González- Pérez
Keywords
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