ANALYSIS OF THE EFFECT OF LEVODOPA ON NITROGENOUS BASES USING QUANTUM METHOD
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
L-3,4-Dihydroxyphenylalanine (DOPA) or Levodopa (Lev) has been used since the 1960s and has become one of the most widely used drugs in neurology. Lev is a metabolic precursor drug for dopamine. Its therapeutic and harmful effects result from its decarboxylation in dopamine through the enzyme decarboxylase. Said metabolic processes can produce genetic mutations, which are the result of the alteration of the nitrogenous bases or the loss of some of them, giving rise to a disturbance in the formation of proteins. The objective of the study is to determine, using the parametric semi-empirical quantum method 3 (SE-PM3), that Nitrogenous Bases (NB) have a higher affinity with Lev. Through Hyperchem Professional software, it is possible to perform molecular models and analysis of the Lev and NB. The result of the simulations shows that there is a loss of electrons from the NB Guanine, which can be correlated with the beginning of serious problems, forming a variety of complex molecules, resulting in the onset of genetic diseases.
Authors and Affiliations
Dr. Manuel González- Pérez
Keywords
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