Analysis of the Efficacy of Cyclophosphamide in Frequently Relapsing and Steroid Dependent Nephrotic Syndrome
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Background: Idiopathic nephrotic syndrome (NS) is one of the common causes of pediatric ward admissions. Although majority of children do not relapse frequently, significant percentage of children with NS goes either for frequent relapses or steroid dependence. Various immunomodulators are used in the treatment of these children including cyclophosphamide. Objectives: To analyze and compare the efficacy of oral and intravenous cyclophosphamide therapy in children with frequently relapsing and steroid dependent NS and also recording the side effects. Materials and Methods: Prospective interventional study on 27 children admitted with a history of frequent relapsing and steroid dependent NS was randomized to receive either oral or intravenous cyclophosphamide, and the results were compared. The study period was 2 years. Results: The mean proteinuria free days with oral and intravenous cyclophosphamide were 180 and 285, respectively. 14.8% of the children developed nausea and vomiting and 3.7% developed alopecia. None developed either leucopenia or hemorrhagic cystitis.
Authors and Affiliations
B Sarath Balaji, Chitra Ayyappan
Keywords
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