ANALYSIS OF THE INTERACTIONS OF N-(L-Α-ASPARTIL)-L-PHENYLALANINE, 1-METIL ESTER (ASPARTAME) AND THE NITROGEN BASES OF DNA AND RNA USING QUANTUM METHODS.
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 5
Abstract
There is much research going on around the ASP. Some of these studies claim that ASP is a potential carcinogen, while others claim otherwise. In this research, we determine the power to exchange electrons of the ASP through the calculation of their Electron Transfer Coefficient (ETC). The quantum methodology was used with the Hyperchem simulator and the Semi-empirical Parametric Method 3 (SE-PM3) with its specific parameters. The results show that the ASP has an ETC capable of interchanging its electrons as an oxidizing agent or reducing agent in a probable interaction zone. It is concluded that for this reason of average probability the results of this investigation sometimes show if and sometimes not their cancerous power. It is then said that its carcinogenic power depends on the conditions under which the laboratory test is performed.
Authors and Affiliations
Dr. Manuel González-Perez
Keywords
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