Analysis of Urinary Organic Acid Profile in Clinically Suspected Patients
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 3
Abstract
Background: Qualitative urinary organic acid profile analysis with gas chromatography/mass spectrometry is used in the diagnosing and monitoring of organic acid disorders. The aim of this study is to verify organic acid testing using diagnostic sensitivity and specificity in routine clinical laboratory. Methods: Cutoff limits of urinary organic acids were determined as the 95th percentile of healthy volunteers’ results. Data of patients submitted to our laboratory were evaluated. Out of 900 clinically suspected patients 25 were diagnosed with 9 different organic acid disorders. Results: Results of diagnostic compounds of patients with organic acid disorders were higher than cutoff limits. This reflects sensitivity. Median values of organic acids of the patient group with no specific organic acidemia were all below the cutoff limit which reflects the specificity of the test. Conclusion: We suggest that routine laboratories should determine their own cutoff limits and evaluate the overall effectiveness for urinary organic acid profile analysis.
Authors and Affiliations
Sezer Uysal, Canan Çoker, Yeşim Öztürk, Nur Arslan
Keywords
Related Articles
- EP ID EP39978
- DOI -
- Views 293
- Downloads 0
Medical Ethics: Awareness about Consent and Documentation among Medical Interns, University of Dammam, Saudi Arabia
Background: Obtaining informed consent is a legal and ethical necessity before treating a patient. Interns are considered to have the same duties about consent and documentation as licensed physicians. The aim of the p...
Prevalence and Factors Contributed to Absenteeism among Nursing Students at Faculty of Nursing Sciences, University of Khartoum –Sudan
Introduction: Student absenteeism is a major concern for university education worldwide. Despite the strict rules, Absenteeism is an ongoing problem in universities. Absenteeism refers to a situation when a student does...
Knowledge of oral health among Diabetic patients of Peshawar, Pakistan
Background: Diabetes Mellitus is considered as a risk factor for initiation and progression of oral diseases. Objectives: To assess the knowledge of oral health and care of oral hygiene among diabetic patients of Peshaw...
The Magnitude of Obesity and its relationship to Blood Pressure among Punjabi Residents of Delhi
Background: Body mass index (BMI) is an important tool for assessing nutritional status. Increased cases of obesity, hypertension and cardiovascular diseases particularly among adults in developing countries, requires d...
Assessing the Risk of Venous Thromboembolism in Psychiatric Patients on Antipsychotic Medication Using Platelet Indices
Background: Psychiatric patents have a predisposition towards developing venous thromboembolism (VTE). This risk is largely related to the medications used in treating the disorders. The objective of the study was to as...