Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC

Abstract

Aim and objective A simple, précised, accurate method was developed for the estimation of Crizotinib by RP HPLC technique. Chromatographic conditions used are stationary phase BDS 250x4.6 mm, 5µ. Mobile phase buffer Methodology Acetonitrile in the ratio of 60 40 and flow rate was maintained at1ml min, detection wave length was 267 nm, column temperature was set to 30o C and diluents was methanol water System suitability parameters were studied by injecting the standard five times and results were well 50 50 , Results and Discussion Conditions were finalized as optimized method under acceptance criteria. Linearity study was carried out between 25 to 150 levels, r2 value was found to be as 0.999. Precision was found to be 1.26 for repeatability and 0.93 for intermediate precision. LOD and LOQ are 0.080 ug ml. By using above method assay of marketed formulation was carried out 100.24 was present. Prapulla Putta "Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23582.pdf Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/23582/analytical-methods-development-and-validation-of-naproxen-and-sumatriptan-by-rp-hplc/prapulla-putta

Authors and Affiliations

Keywords

Related Articles

Document Ranking using Customizes Vector Method

Information retrieval (IR) system is about positioning reports utilizing client's question and get the important records from extensive dataset. Archive positioning is fundamentally looking the pertinent record as per th...

Artificial Intelligence Empowering the Future of Digital Transformation

Artificial Intelligence is not only about the machines that play an authoritative role in humans, but they both are working together. Machines provide the human with the ability of insight and perspective but the machine...

Assembly Line Balancing to Improve Productivity using Work Sharing Method in Garment Factories

The garment factories are always trying to improve production and the quality of the garments to sustain in the enormous competitive market. This paper is about the productivity improvement by reducing cycle time with wo...

Study of Bricks Made Up of Different Materials in Building Construction by eTabs Software

No construction work is possible without bricks because of bricks are used in buildings as well as in pavement. Since many centuries brick making has been practiced by human beings, presently bricks are easily made by th...

Building and Deploying a Static Application using Jenkins and Docker in AWS

Although there are many ways to deploy the Jenkins open source automation server on Amazon Web Services AWS , this whitepaper focuses on two specific approaches. First, the traditional deployment on top of Amazon Elastic...

Download PDF file
  • EP ID EP595145
  • DOI 10.31142/ijtsrd23582
  • Views 56
  • Downloads 0

How To Cite

(2019). Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC. International Journal of Trend in Scientific Research and Development, 3(4), 325-327. https://europub.co.uk/articles/-A-595145