Analyzing the Cryptome: Uncovering Secret Sequences
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 2
Abstract
The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.
Authors and Affiliations
Parimal Samir, Andrew J. Link
Keywords
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- EP ID EP681313
- DOI 10.1208/s12248-011-9252-2
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