Anandaraja Formula or Friedewald Formula, which is a Better Formula for Calculating LDL Cholesterol in Comparision with Direct LDL - Measurement by Homogenous Assay Method
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: LDL Cholesterol is very important marker of atherosclerosis and is used as a predictor to assess coronary heart disease. This study was done to compare the level of LDL by direct method, Friedewald formula and Anandaraja formula. Material and Methods: A cross-sectional study of 156 subjects, lipid profile with TG<400mg/dl in the department of Biochemistry, Varun arjun Medical College and Rohilkhand hospital, Shahjahanpur(UP) from September 2016 to November 2016. Lipid profile were measured by ERBA EM 200 fully autoanalyser as per laboratory standard practices. LDL-C was estimated by direct LDL, Friedwald Formula and Anandaraja Formula. Results: Out of 156 subjects, 58.3% were male and 41.7% were female. The mean age of the patients were 47.8±14.6yrs. Lipid profile were assayed by fully autoanalyzer. The mean LDL were 102.1±37.7, 95.4±36.4 and 104.8±14.6 for direct LDL, Friedewald LDL and Anandaraja LDL. A good correlation was found between FLDL-C and DLDL-C(r=0.876) and also ALDL-C and DLDLC( r=0.844) Conclusion: Friedewald formula shows a strong correlation(0.876) in comparison with Anandaraja formula(0.844) when both these methods are correlated with Direct homogenous method for calculating LDL-Cholesterol.
Authors and Affiliations
Niranjan Singh, B J Pradeep Kumar, K V Thimmaraju, K Kalyan Kumar, Bindu Sharma, Ajai Kumar
Keywords
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