Anaplastic meningioma: The dark side of meningiomas
Journal Title: RESEARCH AND CLINICAL MEDICINE - Year 2017, Vol 0, Issue 2
Abstract
Anaplastic meningioma is a rare malignant tumor of the meninges, with a very aggressive behavior and a grim prognosis. Here we report a case of a 64-year old man which presented to the neurosurgery department with motor deficit in the right hemi–body, loss of speech and disorientation. Magnetic resonance imaging detected a mass located in the left frontal lobe that measured 7/8/7 cm, leading to the conclusion that surgery is necessary. Microscopic examination of the tumor showed great number of hypercellular areas with a high mitotic index, and focal necrosis with psammoma bodies. Using a panel of antibodies such as EMA, vimentin, CD34 GFAP, pancytokeratin and Ki67, we concluded that he final diagnosis was anaplastic meningioma, WHO grade III. Due to its morphological similarity with other tumors, the diagnosis of anaplastic meningioma may be challenging.
Therapeutic potential of angiogenesis inhibitor mixtures in cancer treatment
It is generally understood that improvement of cancer therapies is achieved by the combination of drugs. This approach will improve efficacy, while toxicity and the risk for drug resistance may be decreased. In this revi...
Morphologic changes in the injured anterior cruciate ligament (ACL) correlated with the expressions of protein S100 AND NFAP: Major therapeutic implications or a wrong gateway towards improving ACL reconstruction ?
Objectives: We examined the histoarchitecture of the anterior cruciate ligament [ACL] stumps in different stages of evolution after injury and we analyzed the correlation with the expressions of protein S100 and neurofil...
Results of peginterferon alpha-2a treatment in patients with chronic hepatitis B in the Western part of Romania
Objective: Currently there are two major types of antiviral therapy in HBV chronic liver disease: PegInterferon alpha-2a and nucleoside/ nucleotide agents. The aim of this study was to evaluate the response to PegInterfe...
Anaplastic meningioma: The dark side of meningiomas
Anaplastic meningioma is a rare malignant tumor of the meninges, with a very aggressive behavior and a grim prognosis. Here we report a case of a 64-year old man which presented to the neurosurgery department with motor...
Expression of CK5 basal cytokeratin during metastatic development of breast carcinoma
Objective. Breast cancer is a one of the most common cancers in females worldwide. Basal cytokeratin CK5 represent the marker of progenitors for glandular and myoepithelial lineages of mammary epithelium. During epitheli...