ANDROGEN RECEPTOR POSITIVITY IN TRIPLE-NEGATIVE BREAST CANCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 36
Abstract
BACKGROUND Triple-Negative Breast Cancers (TNBC) is an enigmatic group of breast cancers with rising trend. The presence of Androgen Receptor (AR) in Oestrogen Receptor (ER) negative cases is 30%, in TNBC the AR positivity is < 20%. Aim: This study is done to know the percentage of AR in TNBC in this population. MATERIALS AND METHODS This is a retrospective descriptive study. The total breast cancer patients between the periods of October 2014 and February 2014 were 734 cases. 72 cases were triple-negative breast cancer cases as demonstrated by the immunohistochemistry. Androgen receptor was considered positive if > 10% of cells showed positivity on immunohistochemistry. RESULTS Androgen receptor is negative amongst a majority of 88% of patients with 12% remaining AR positive, of which 8% is high, 3 medium and 1 low positive. The percentage of AR positivity in TNBC in this study concurs with the literature findings. CONCLUSION This explains the importance of the same in TNBC, as it seems to be an important avenue for therapeutic targeting, because this group of patients do not have much options for treatment. Further studies with the use of androgen receptor blockade through drugs like Bicalutamide/Enzalutamide/Abiraterone in AR-positive TNBC could be studied to know the survival improvement.
Authors and Affiliations
P. Jovita M. Martin, Kalaichelvi K, Suresh Kumar
Keywords
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- EP ID EP544953
- DOI 10.14260/jemds/2018/885
- Views 91
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