Anemia in patients with type II diabetes mellitus with and without diabetic retinopathy
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 2
Abstract
Background: Anemia has been recognized as a chronic complication of diabetes mellitus. Oxidative stress created by chronic hyperglycemia leads to RBC damage and is involved in the pathogenesis of anemia. Anemia induced hypoxia leads to vaso-proliferation in the retina and in turn to development and deterioration of diabetic retinopathy. Objective: The aim of the study was to find out whether anemia is prevalent in cases of type II diabetes mellitus (DM). To find out whether there exist a relationship between anemia and diabetic retinopathy. Materials and Methods: The study was done on total 135 subjects. The control group (Group-A) included 45 age and sex matched healthy subjects. The case group was divided into 2 groups, 45 subjects diagnosed with type II DM without diabetic retinopathy (Group-B) and 45 subjects of type II DM with diabetic retinopathy (Group-C). The mean hemoglobin level, total red blood cell (RBC) count and packed cell volume (PCV) were compared in 2 groups. Result: The mean hemoglobin level in Group-A, B, and C were 14.23±0.83 gm/dl, 12.22±0.11 gm/dl, and 10.44±0.23 gm/dl, respectively (p<0.001). The mean PCV in Group-A, B, and C were 44.21±0.34%, 41.11±1.22%, and 37.86±1.12%, respectively (p<0.001). The mean RBC count in Group-A was 5.9 ±0.11 million/mm3 , Group-B was 5.4±0.83 million/mm3 , and in the Group-C was 4.6±1.3 million/ mm3 . The mean hemoglobin level, RBC count, and PCV were found to be significantly lower in subjects with diabetes as compared to non-diabetic subjects. The values were further statistically significantly lower in diabetic subjects with retinopathy. Conclusion: We conclude that unrecognized anemia exists in diabetic subjects. The severity of anemia is greater in subjects with retinopathy. It is suggested that the hematological parameters should be evaluated and treated periodically in diabetic patients to reduce the load, of ocular morbidity due to retinopathy.
Authors and Affiliations
Shikha Baisakhiya, Punita Garg, Surjit Singh
Keywords
Related Articles
- EP ID EP300616
- DOI 10.5455/ijmsph.2017.03082016604
- Views 66
- Downloads 0
Study on awareness of road traffic rules among drivers of rural area: A cross-sectional study
Background:Road traffic accidents (RTA) are a pandemic in current era, which destined to rise in the future, due to increase in a number of vehicular population in addition to increase in a number of aggressive road user...
An assessment of community participation in control and prevention of Japanese encephalitis in rural Uttar Pradesh
Background: Mosquito-borne disease poses a great burden to the society. It can be easily prevented through appropriate knowledge, positive attitude, and good practices. Japanese encephalitis (JE) is among one of these di...
Awareness to health hazards and biosafety precautions among laboratory technicians working in tertiary-care center in Rajasthan, India
Background: Awareness to health hazards and biosafety precautions among laboratory workers is an important aspect. Technicians handle blood or any biological sample may be at risk for accidental injury or exposure. The...
Genetic diversity in MSP-1 gene of Plasmodium falciparum and its association with malaria severity, parasite density, and host factors of asymptomatic and symptomatic patients in Papua, Indonesia
Background: Genetic diversity of Plasmodium falciparum represents a major issue in understanding the several aspects of malaria infection and diseases. The merozoite surface protein (MSP)-1 gene of P. falciparu...
Gender disparity in health and nutritional status among under-five children in a rural field practice area of Shri BM Patil Medical College
Background: It is the right of every child to know and be cared for by his/her parents. The responsibilities for the child’s well-being rely on both the parents and the society. Since the ancient times, it is the gen...