Animal experimental study of a new aortic arch fenestrated stent graft
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6
Abstract
Objective To evaluate the safety and efficacy of a novel aortic arch fenestrated membrane-covered stent graft implanted in situ in large animals after long-term maintenance. Methods Three healthy male Large White pigs (named PD01, PD05, PZ02 respectively), weighing 86-150 kg and aged 12-14 months, were selected. Under general anesthesia and intubation, thoracotomy was performed through the fourth intercostal space on the left side of the pigs to establish extracorporeal circulation. The aortic arch fenestrated covered stent was implanted by incising the aorta. Postoperative follow-up was conducted for 6 months, with safety and efficacy analyzed through routine blood tests, biochemical indices, ultrasonography, angiography, dissection, and pathology. Results In all three animals, postoperative levels of red blood cells, plasma hemoglobin, hematocrit, and platelets remained stable. The ALT of three animals elevated immediately after operation, the AST only elevated in PZ02. The albumin of three animals decreased and the levels of serum creatinine and blood urea nitrogen increased immediately after operation. All the indexes returned to normal along with time. Cardiac ultrasound results after the implantation of the aortic arch fenestrated covered stent showed no significant clinical signs of aortic valve stenosis in terms of transvalvular pressure gradient and blood flow velocity until the endpoint. Digital subtraction angiography revealed that the positioning of the fenestrated covered stents was satisfactory, with no instances of displacement or other adverse phenomena. No obvious thrombosis, perforation, or infection occurred in the experimental animals. Conclusion The novel aortic arch fenestrated covered stent system meets the basic requirements for artificial vascular substitutes. It can simplify surgical procedures, shorten operation time, and reduce the incidence of postoperative complications. Additionally, this stent system exhibits good tissue compatibility and safety.
Authors and Affiliations
XU Can, PAN Jun, ZHOU Qing, WANG Dongjin
Keywords
Related Articles
- EP ID EP738307
- DOI 10.13429/j.cnki.cjcr.2024.06.005
- Views 24
- Downloads 0
Correlation between cardiometabolic index and stroke in middle-aged and older adults
Objective To explore the relationship between cardiac metabolic index (CMI) and stroke in middle-aged and elderly individuals based on a large sample cohort study. Methods Data were obtained from the China Health and Ret...
Effect and clinical efficacy of Ginkgo biloba tablets on fibroblast growth factor 4 in patients with unstable angina pectoris
Objective To explore the therapeutic effect of Ginkgo biloba tablets on patients with unstable angina and their impact on fibroblast growth factor 4 (FGF-4). Methods From January 2022 to September 2023, 360 patients with...
Bronchoscopic lavage-assisted treatment of Mycoplasma pneumonia in children：a Meta-analysis of randomized controlled trials
"Objective To systematically evaluate the clinical efficacy of bronchoscopic lavage-assisted treatment of Mycoplasma pneumonia (MP) in children, providing references for clinical treatment. Methods China National Knowl...
Laparoscopic hepatectomy and open hepatectomy in treatment of hepatocellular carcinoma
Objective To explore the perioperative situation of patients with hepatocellular carcinoma (HCC) treated with laparoscopic hepatectomy or open hepatectomy and their effects on liver function. Methods A retrospective anal...
Research progress of gene detection in systemic therapy of pancreatic cancer
Pancreatic cancer is a common highly malignant digestive tract tumor. Due to its location and disease characteristics, it presents significant challenges in treatment. The molecular diversity of pancreatic cancer contrib...