ANKK1 gene in psychiatry
Journal Title: Psychiatria Polska - Year 2011, Vol 45, Issue 3
Abstract
Summary According to last findings, one of the most commonly studied polymorphisms in psychiatry- Taq1A is located in the ANNK1(Ankyrin Repeat and Kinase Domain containing 1) gene, not in the dopamine receptor 2 (DRD2) gene. This polymorphism has been extensively studied in relation to alcohol, nicotine and drugs addiction, eating disorders, ADHD, schizophrenia and pharmacogenetics. The ANKK1 gene contains single serine/threonine kinase domain and 11 ankyrin repeats. ANKK1 belongs to RIP (Receptor-Interacting Protein) serine/threonine kinase family. These kinases are important in cell proliferation, differentiation and activate transcription factors. DRD2 gene is probably regulated by ANKK1 through NF-kB (Nuclear Factor-kappaB). ANKK1 is activated by apomorphine- dopaminergic agonist, which indicates another link with the dopaminergic system. It seems accurate to search for associations of polymorphisms in ANKK1 gene with dopaminergic system disorders.
Authors and Affiliations
Aleksandra Suchanecka, Anna Grzywacz, Jerzy Samochowiec
Keywords
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