Ankle Brachial Index in Children with Steroid-Resistant Nephrotic Syndrome
Journal Title: Sultan Qaboos University Medical Journal - Year 2013, Vol 13, Issue 1
Abstract
Objectives: Tis study aimed to assess the ankle brachial index (ABI) as a predictor of peripheral arterial diseases (PAD) in children with steroid-resistant nephrotic syndrome (NS). Methods: Twenty children (11 males and 9 females) attending the Pediatric Nephrology Outpatient Clinic of El-Minia University Hospital, Egypt, were enrolled in this study. Teir age ranged between 5 and 15 years with a mean of 10.75 ± 3.31 years. Tey had proteinuria and were dependent on steroid therapy. Twenty healthy age- and sex-matched children served as a control group. All patients and controls underwent a thorough history-taking and clinical examination. All subjects in the study underwent laboratory investigations, including a urine analysis (24-hour test for protein in urine, and levels of serum urea and creatinine, triglycerides, and cholesterol). A renal biopsy was done to diagnose the children’s histopathological type of NS. A Doppler study was done to determine patients’ ABI. Results: ABI was signifcantly higher in the patient group than in the control group (P <0.0001). Tere was a negative correlation between ABI and duration of treatment (r value = 0.77 and P <0.001). Conclusion: ABI is simple non-invasive manoeuvre that can reliably assess arterial stiffness as an early predictor of atherosclerosis in nephrotic patients with long duration of both illness and steroid therapy.
Authors and Affiliations
Sheren M. Mohamed| Departments of Pediatrics, El-Minia University Hospital, Minia, Egypt, Abdelazem Elmazary| Departments of Pediatrics, El-Minia University Hospital, Minia, Egypt, Hany T. Taha| Departments of Cardiology, El-Minia University Hospital, Minia, Egypt
Keywords
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