Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model
Journal Title: Health Problems of Civilization - Year 2019, Vol 13, Issue 1
Abstract
Background It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (LCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model. Material and methods Male albino Swiss mice, after receiving a combination of LCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs. Results Type I isobolographic analysis revealed that the combination of LCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model. Conclusions Since the three-drug mixture of LCM, CBZ and VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.
Authors and Affiliations
Maria W. Kondrat-Wróbel, Katarzyna Załuska, Aleksandra Walczak, Anna N. Panasiuk-Poterek, Agata Gut-Lepiech, Paula Wróblewska-Łuczka, Jarogniew J. Łuszczki
Keywords
Related Articles
- EP ID EP492100
- DOI 10.5114/hpc.2019.81105
- Views 73
- Downloads 0
Vascular related pathologies in cardiovascular disease and cancer
Cancer and Cardiovascular diseases (CVD) are the two most prominent causes of death worldwide. Emerging evidence indicates shared risk factors and a common biology between these diseases. For instance, chronic inflammati...
HEALTH 2020 AND ACTION PLAN FOR PUBLIC HEALTH – NEW UNDERSTANDING OF PUBLIC HEALTH
.
PHYSICAL ACTIVITY OF THE STUDENTS FROM UNIVERSITIES IN BIAILA PODLASKA IN THEIR FREE TIME ACCORDING T0 THE CHOSEN FACULTIES
The aim of the research was to acquire knowledge about students’ physical activity in their free time according to their chosen faculties. Subject of the research were the students from seven faculties in two universitie...
TREATMENT RESULTS EVALUATION IN PATIENTS WITH SEVERE SEPSIS, CAUSED BY SEVERE TRAUMATIC BRAIN INJURY AT INTENSIVE CARE UNIT OF TERNOPIL UNIVERSITY HOSPITAL
Background. Severe traumatic brain injury stays one of the main reasons of humans’ mortality until the age of 40. Ternopil University Hospital delivers medical care to the patients with neurosurgical pathology of Ternopi...
Life satisfaction in women after mastectomy – a pilot study
Background Cancer is the second most common cause of morbidity and mortality in Poland and breast cancer is the most frequent malignant neoplasm occurring in Polish women. The aim of this paper is to analyse life satisfa...