Antenatal Corticosteroid Therapy Prevents Preterm Birth Related Complications
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Preterm birth complications, is a major killer of under 5 children. We are far behind to achieve Millennium Development Goal 4 (MDG 4), targeted to reduce under-five mortality rate by two-third. In 2015, WHO strongly recommends antenatal corticosteroid single or double dose during preterm labour to prevent preterm related complications. Data on antenatal corticosteroid use, and outcomes including safety were absent in nearly all countries. This study aimed to assess the effectiveness of antenatal corticosteroid on prevention of preterm birth related complications. Also to assess the risk factors associated and outcome of antenatal corticosteroid therapy in terms of mortality/ morbidity in preterm infants. This cross sectional, prospective and hospital based observational study conducted during December 2015 to November 2016 in the Special new born care unit of a tertiary care hospital ,Odisha, India and approved by the Institutional Ethics Committee. 200 preterm babies including both inborn and out born categories, admitted in to the SNCU level II were enrolled in this study. The demographic data like mother’s age, baby’s gestational age , normal age, sex, birth weight, regular antenatal check up and the detailed data about the antenatal corticosteroid therapy, were recorded from hospital record and asking questions to the parents/guardians. The role of antenatal corticosteroid on preterm related complications like RDS, NEC, IVH, PDA and Sepsis as well as treatment outcome were evaluated. The data were analyzed by a statistical software Graph pad prism ver. 7 by a computer by Chi-square test with odd’s ratio. Out born cases, male sex, 28-32wks of gestational age (54.5%), low birth weight ranges from 1000-1500 gms, mothers with age group of 20-25yrs (54.2%) , mothers without antenatal check up were more associated to risk of complications and mortality. There is significant reduction of percentage of complications and death % with ANS treated group than without ANS group
Authors and Affiliations
Narendra Behera, Jayanti Prava Behera, Dash Nishanta Nilotpala
Keywords
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