ANTI-ANXIETY EVALUATION OF EXTRACTS OF STIGMA MAYDIS (CORN SILK)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: The anxiolytic activity of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis was investigated by Elevated Plus Maze, Hole Board and Mirror Chamber Test.Methods: The study was conducted using elevated plus maze, whole board and mirror chamber test. Female Laca/Balb c was used to carry out the studies. In each experiment, animals were equally divided into five groups; control, given saline solution and Tween 80, standard given diazepam (2 mg/kg i. p.) and test groups were given 250, 500, 750 and 1000 mg/kg of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis. The data were subjected to analysis of variance by taking mean and standard error to the mean using Tukey’s post-hoc test.Results: In Elevated Plus Maze chloroform extract (750 and 1000 mg/kg) of Stigma maydis revealed increase in time spent in open arm, frequency and preference to open arm as compared to control, which was almost comparable to diazepam. In Hole Board test decrease in number of head dips as compared to control was observed. In Mirror Chamber Test, the decrease in latency, increase in time spent in the mirror chamber and frequency as compared to control was observed. All of the changes were statistically highly significant.Conclusion: From our results it can be concluded that the chloroform extract of Stigma maydis showed anxiolytic activity at the dose of 750 and 1000 mg/kg.Â
Authors and Affiliations
Devleen Kaur, Divneet Kaur, Navpreet Bains, Anuja Chopra, Poonam Arora
Keywords
Related Articles
- EP ID EP578342
- DOI -
- Views 51
- Downloads 0
ECOLOGY AND THE RAPD TECHNIQUES USED TO ASSESS THE GENETIC DIVERSITY IN PTEROLOBIUM HEXAPETALUM, A SCRAMBLING MEDICINAL SHRUB IN MARUTHAMALAI AND CHENNIMALAI HILLS, THE WESTERN GHATS
Objective: To investigate the ecological and genetic diversity, climatic factors, edaphic factors morphological and reproductive characters and RAPD analysis of medicinal plant species Pterolobium hexapetalum in two hill...
STUDY ON THE INTERACTION OF AMITRIPTYLINE HYDROCHLORIDE AND MALONIC ACID BY SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC METHODS IN TABLETS: APPLICATION TO CONTENT UNIFORMITY TESTING
Objective: The objective of this research to study the interaction between amitriptyline hydrochloride in drug products via reaction with mixed acids anhydrides: Application to Content Uniformity Testing.Methods: Malonic...
GROWTH CHARACTERIZATION OF CALCIUM HYDROGEN PHOSPHATE DIHYDRATE CRYSTALS INFLUENCED BY COSTUS IGNEUS AQUEOUS EXTRACT
Objective: To investigate the inhibitory effect of aqueous extract of leaves, stems and rhizome of Costus igneus on the growth of calcium hydrogen phosphate dihydrate (CHPD) crystals.Methods: Calcium hydrogen phosphate d...
Screening, MeSCREENING, MEDIA OPTIMIZATION AND PARTIAL PURIFICATION OF PROTEASE BY TRICHOSPORON JAPONICUM VITVK1dia Optimization and Partial Purification of Protease by Trichosporon japonicum VITVK1
Objective: The main aim of the study was to screen, optimize and partial purification of protease from fungi. The isolated fungi were screened for protease activity on a modified SDA plate and subjected to media optimiza...
EFFECT OF METHANOLIC FRACTION OF KALANCHOE CRENATA ON RENAL MORPHOPHYSIOLOGY IN ADRIAMYCIN-INDUCED IMPAIRED KIDNEY IN RATS
Objectives: The effect of methanolic extract of Kalanchoe crenata (MEKC) was investigated on renal morphology and function in adriamycin-induced kidney impairment in rats.Methods: Ether anesthetized rats received three i...