Anti-apoptotic effects of hyperoside via inhibition of NR2B-containing NMDA receptors.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 5
Abstract
Hyperoside (Hyp) is a flavonoid compound isolated from a folk remedy, Rhododendron ponticum L. leaves. It has been shown to have neuroprotective effects both in vivo and in vitro. However, little is known about the effects of Hyp on the neuronal apoptosis induced by glutamate. The present study showed that Hyp significantly attenuated, in a concentration-dependent manner, the apoptosis induced by the exposure of cultured neurons to NMDA. Western blot analysis revealed that Hyp antagonized the expression of excess NR2B-containing NMDA receptors; however, it had no effect on the expression of NR2A-containing NMDA receptors. Our results demonstrate that the neuroprotective effect of Hyp owes, at least partially, to its differential modulation of NR2A- and NR2B-containing NMDA receptors.
Authors and Affiliations
Xiao-Nan Zhang, Jin-Mao Li, Qi Yang, Bin Feng, Shui-Bing Liu, Zhao-Hui Xu, Yan-Yan Guo, Ming-Gao Zhao
Keywords
Related Articles
- EP ID EP144859
- DOI -
- Views 78
- Downloads 0
Editorial.
The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment.
The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2B measured as a rate of 16beta-hydroxylation of testosterone. The reaction was studied in cont...
Effect of the combined administration of ethanol and acamprosate on rabbit EEG.
Central effect of ethyl alcohol and acamprosate is based on similar mechanisms. It is mainly connected with their effect on GABAergic, glutamatergic, serotonergic and opioid transmission. Thus, the question arises whethe...
Assessment of vascular disease using arterial flow mediated dilatation.
Arterial endothelial dysfunction occurs at all stages of atherosclerosis, both preceding structural atherosclerosis changes, as well as predisposing to clinical events in late obstructive disease. Endothelial dysfunction...
Impact of the changes in P-glycoprotein activity on domperidone pharmacokinetics in rat plasma.
The effect of quinidine (QD) and grapefruit juice (GFJ) extract, P-glycoprotein inhibitors, on the domperidone (DOM) concentration in rat plasma was investigated. DOM, a dopamine D(2)-receptor antagonist is a substrate f...