ANTI ARTHRITIC ACTIVITY OF CAESALPINIA PULCHERRIMA AGAINST TYPE II COLLAGEN INDUCED ARTHRITIS IN EXPERIMENTAL RATS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 2
Abstract
Caesalpinia pulcherrima is a medicinal plant belonging to the family Caesalpiniaceae. The main aim of the present study was to investigate the Anti Arthritic activity of the ethanolic extract of Caesalpinia pulcherrima (ECP) at the dose of 200 mg/kg and 400 mg/kg on Type II Collagen induced Arthritis in experimental rats. In collagen induced arthritic rats, there was significant enhance in rat paw volume and reduce in body weight, whereas ECP and Aspirin treated groups showed significant decrease in paw volume and normal gain in body weight. The altered hematological parameters (Hb, RBC, WBC, ESR and CRP) in the arthritic rats were significantly recover to normal by administration of ECP. Further the radiological studies revealed the anti arthritic activity of ECP by indicating less abnormality in extract treated groups when compared to the arthritic control group. Findings from the present investigations suggest that the ethonolic extract of Caesalpinia pulcherrima exhibits significant anti arthritic activity.
Authors and Affiliations
C Rajaram, K Ravindra Reddy, K B Chandra Sekhar
Keywords
Related Articles
- EP ID EP625064
- DOI -
- Views 61
- Downloads 0
METHOD DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN IN API BY RP-HPLC AND UV-SPECTROSCOPY
In the present study, two analytical methods were developed for the estimation of Dapagliflozin in API. Method A: RP-HPLC method, Method B: UV spectroscopic method. In method A, the drug showed linearity in the range of...
CHEMICAL PROFILING BY GC/MS ANALYSIS OF NON-POLAR EXTRACTS OF ERYNGIUM GLAZIOVIANUM (APIACEAE)
GC/MS was used as a tool to achieve the chemical profiling of n-hexane extracts from flowers, leaves and stems of plant species Eryngium glaziovianum L. (Apiaceae), an ornamental plant commonly found in several states of...
OPTIMIZATION OF CILNIDIPINE NANOSUSPENSION USING A CENTER COMPOSITE DESIGN
The purpose of this investigation was to increase the solubility and dissolution rate of Cilnidipine by the preparation of nanosuspensions with solvent antisolvent method at the laboratory scale. Drug solution of Cilnidi...
GENE THERAPY OF CANCEROUS DISEASES
Gene therapy of cancerous diseases provides new means of curing patients with oncologic illnesses. There are several approaches in treating cancer by gene therapy. Most commonly used methods are: cancer immunogene therap...
NEUROPROTECTIVE EFFECT OF RESVERATROL ON VALPROIC ACID INDUCED OXIDATIVE STRESS AUTISM IN SWISS ALBINO MICE
The present research work is aimed to investigate the anti-oxidant/neuroprotective role of Resveratrol in reversing the valproic acid induced autism in postnatal swiss albino mice. Separate 13 day old/ Post natal day (PN...