ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF MOMORDICA CHARANTIA AGAINST FCA INDUCED ARTHRITIS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 6
Abstract
The present investigation is aimed to evaluate anti-arthritic activity of the ethanol extract of root of Momordica charantia (EEMR) by using Freund’s complete adjuvant (FCA) induced arthritis model which is a extensively used model for in-vivo study of anti-arthritic activity. Arthritis assessment was carried out on basis of parameters i.e. arthritis score, joint diameter and paw volume. The standard drug was diclofenac sodium. The findings of present study showed that EEMR in dose of 400 mg/kg produced more significant reduction in arthritis score, joint diameter and paw volume as compare to 200 mg/kg. On the basis of results, it can be concluded that EEMR showed significant anti-arthritic activity. It may be due to presence of phytocompounds such as flavonoids, alkaloids, tannins etc.
Authors and Affiliations
Lekhni Soni, Rupesh K Gautam
Keywords
Related Articles
- EP ID EP625210
- DOI 10.25004/IJPSDR.2016.080604
- Views 104
- Downloads 0
FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF STAVUDINE GASTRO RETENTIVE FLOATING MATRIX TABLETS
The aim of the present investigation was to develop floating matrix tablets of stavudine to achieve prolong gastric residence time, leading to an increase in drug bioavailability and patient compliance. Floating tablets...
RENAL VASCULARISATION CAUSING END - STAGE FAILURES AND OUTCOMES: A POOLED ANALYSIS OF COMMUNITY BASED STUDIES
Although acute renal failure (ARF) is believed to be common in the setting of critical illness and is associated with a high risk of death, little is known about its epidemiology and outcome or how these vary in differen...
EFFECT OF LEUKOTRIENE RECEPTOR ANTAGONIST MONTELUKAST ALONG WITH CURCUMIN AGAINST GASTRIC ULCERATION
Curcumin, a yellow pigment in the spice turmeric, has been used for centuries as a treatment for inflammatory diseases. This yellow pigment has anti-secretary property in different experimental ulcer models. Montelukast,...
ANTIDIABETIC ACTIVITY OF EXTRACTS OF PITHECELLOBIUM DULCE BENTH LEAVES IN ALLOXAN INDUCED DIABETIC RATS
The objective of the present study was to study effect of Pithecellobium dulce Benth (P. dulce) leaves in alloxan induced diabetic rats. The P. dulce leaves were extracted by maceration and soxhelation method by using wa...
A NOVEL TECHNIQUE TO ENHANCE DISSOLUTION RATE OF CILNIDIPINE USING LIQUISOLID COMPACT & WET GRANULATION
The main objective of the work was to improve the dissolution rate of the drug, Cilnidipine (CLD) by using the liquisolid compact technique and wet granulation. Cilnidipine drug is poorly soluble in water and it’s highly...