ANTI-ARTHRITIC ACTIVITY OF PORTULACA OLARACEA L. SATIVA ON ANIMAL MODELS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
The present study was designed to investigate anti-arthritic activity of Portulaca olaraceal. sativa leaves in rats. Arthritis was induced in rats in all groups of animals by injecting 0.05 ml of 0.5(w/v) suspension of killed Mycobacterium tuberculosis in paraffin oil into the left hind limb. Preliminary extraction was subjected to acute oral toxicity study according to the OECD guidelines no 423. Based on that, two dose levels i.e. 200 and 300mg/kg were selected for further study. Oral administration of the extract showed the significant results in Freund’s adjuvant induced arthritis in rats. The biochemical study of EEPO (200mg/kg & 300mg/kg) showed the increase WBC count was significantly suppressed and standard diclofenac sodium (P<0.01).The increased lymphocyte count in adjuvant control group was significantly restored back to normal by test and standard drug (P<0.01).There is a decreased protein content in standard and extract drug treatment group as compared to adjuvant control group.
Authors and Affiliations
Rajinikar Reddy, V. Rajesham, S. Kiran Kumar, J. Prasanna kumari
Keywords
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