ANTI-ATHEROSCLEROTIC ACTIVITY OF ELAEOCARPUS GANITRUS ROXB. IN CHOLESTEROL-FED RABBITS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 12
Abstract
  Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against atherosclerosis.Methods: Anti-atherosclerotic activity of E. ganitrus extract was evaluated at a dose level of 250 and 500 mg/kg of body weight (p.o). On 121st day, the animals were sacrificed to collect the aorta for determining tissue lipid profile, antioxidant parameters, and histopathological changes. One-way ANOVA followed by Tukey’s multiple comparison test was used for the statistical analysis.Results: Aorta of cholesterol-fed rabbits for 120 days showed marked elevation in total cholesterol, triglycerides, and phospholipids. EEGS extract treatment significantly (p≤0.01, ≤0.001) corrected disturbed lipid profile in cholesterol-fed rabbits in a dose-dependent manner during the 60 days of the treatment period. A significant reduction in lipid peroxidation and a considerable raise in glutathione, catalase, and superoxide dismutase levels (p≤0.01, ≤0.001) were accompanied by post-treatment with EEGS extract to cholesterol-fed rabbits. The histopathological modifications such as accumulation of foam cells, atheromatous plaque formation, and lumen size reduction supported the successful induction of atherosclerosis in rabbits. The treated rabbits showed significant protective effect by lowering the deposition of cholesterol and increasing the lumen size compared to cholesterol-fed group.Conclusions: Phytoconstituents such as alkaloids, tannins, flavonoids, steroids, triterpenoids, and carbohydrates in the ethanolic extract may be attributed to effective anti-atherosclerotic and antioxidant activity of plant extract. Our study exhibited that EEGS extract could be a potent herbal therapeutic agent for the treatment of atherosclerosis and hypercholesterolemia-related diseases.
Authors and Affiliations
Pratibha Kumari Jain, Priyanka Sharma, Suresh C Joshi
Keywords
Related Articles
- EP ID EP605505
- DOI 10.22159/ajpcr.2017.v10i12.20111
- Views 86
- Downloads 0
PRESCRIPTION WRITING PRACTICES AND ERRORS IN PRESCRIPTIONS CONTAINING CARDIOVASCULAR DRUGS ESPECIALLY ACE INHIBITORS IN KARACHI, PAKISTAN
ABSTRACTObjective: This is the first study related to the prescribing errors in cardiovascular prescription drugs especially Angiotensin converting enzymeinhibitors (ACEIs) conducted with the aim to identify the prescrib...
FORMULATION OPTIMIZATION AND EVALUATION OF MOUTH DISSOLVING FILM OF APREPITANT
Objectives: The aim of the present research is to prepare mouth dissolving film of aprepitant used in the prevention and treatment of post-operative nausea and vomiting. Methods: The MDF was prepared using Kollicoat IR,...
CARDIOVASCULAR RISK SCREENING SERVICES IN SUDANESE COMMUNITY PHARMACIES
Objectives: The objective of this study was to investigate the Sudanese community pharmacists' knowledge and practice of cardiovascular disease risk assessment services.Methods: The study was conducted as a non-intervent...
TOTAL ANKLE REPLACEMENT FOR TREATMENT OF AVASCULAR NECROSIS OF THE TALUS
Avascular necrosis (AVN) of talus is a well-known complication following talar neck fracture that leads to osteoarthritis of the ankle joint. Tibiotalar fusion is the gold standard of treatment in end-stage ankle osteoar...
PHARMACOGNOSTIC, PHYSICOCHEMICAL, AND PHYTOCHEMICAL STUDIES ON STEM BARK OF ZANTHOXYLUM ARMATUM DC.
Objectives: To analyze the microscopic, macroscopic, physicochemical, and phytochemical standards of the Zanthoxylum armatum DC. (stem bark). Methods: Pharamacognostic studies, namely macroscopic, microscopic, and powde...