Anti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Dulce Benth Fruit Peel On Streptozotocin Induced Diabetic Rats
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2016, Vol 12, Issue 15
Abstract
The decoction of the Pithecellobium dulce fruit peel has been used for the control of diabetes mellitus in the traditional method adopted by the local people of northwest region of Tamil Nadu, India. The present study was carried out to investigate the anti-diabetic potential of aqueous extract of Pithecellobium dulce fruit peel by its oral administration (200 mg/kg) to streptozotocin-induced diabetic rats. The levels of blood glucose, urine sugar, glycosylated hemoglobin, glucose-6-phosphatase, fructose-1,6-bisphosphatase, total cholesterol, triglycerides, aspartate transaminase, alanine transaminase, alkaline phosphatase and reduced glutathione were increased significantly whereas the levels of plasma insulin, hexokinase, protein, liver glycogen, reduced glutathione, superoxide dismutase, catalase and glutathione peroxidase were decreased in streptozotocin-induced diabetic rats and it was normalized after treatment of aqueous extract. Glibenclamide was used as the standard drug. These outcomes suggest that the aqueous extract possesses anti-diabetic activity and supports the traditional use of the Pithecellobium dulce fruit peel decoction as hypoglycemic agent.
Authors and Affiliations
T. A. Sukantha, Shubashini. K. Sripathi, N. T. Ravindran
Keywords
Related Articles
- EP ID EP652951
- DOI 10.24297/jac.v12i15.1920
- Views 248
- Downloads 0
DRY SLIDING WEAR BEHAVIOR OF DIFFUSION BONDED AZ-91 MAGNESIUM ALLOY REINFORCED WITH SIC PARTICLES
Magnesium composites reinforced with 2, 4, 6 Wt.% of silicon carbide particles at different particle size of 10, 25 and 45 mm was synthesized using diffusion bonding process. Further the samples for scanning electron mic...
Synthesis, characterization, antibacterial, antioxidant and anti-inflammatory activities of new 4-Aryl-2-amino-6-(4-hydroxy coumarin-3-yl) pyridine-3-carbonitriles derivatives
This study aimed for the synthesis of 4-Aryl-2-amino-6-(4-hydroxy coumarin-3-yl) pyridine-3-carbonitriles 4 suitable for use as antibacterial, anti-oxidant and anti-inflammatory activities via a versatile, readily access...
Structural Study of a new Compound Based on Acid 1,4-Cyclohexanedicarboxylic (1,4-CDC)
One nickel 1,4-cyclohexanedicarboxylate coordination polymers, Ni2 [(O10C6H4)(COO)2].2H2O Â (I), was hydrothermally synthesized from an aqueous solution of Ni (NO3)2.6H2O, (1,4-CDC) (1,4-CDC = 1,4-cyclohexanedicarboxylic...
Synthesis of nitrogen-containing phenol formaldehyde oligomers,grafted with vegetable oils
Synthesis of nitrogen-containing phenolformaldehyde oligomers (phfo), grafted with vegetable oils is aimed at the acquisition of new range coating materials. Oil has been used as an example of soybean and linseed oils....
Measurement Natural Radioactivity in Soil Samples from Important historical locals in Alnajaf Alashraf city, Iraq.
Al-Najaf Al-Ashraf city one of the most important ,oldest, historical and religious cities in Iraqi country which includes hundreds of holy shrines and historical mosques which over the built hundreds of years. The natur...