ANTI-DIABETIC ACTIVITY OF TRICHODESMA INDICUM (L.) LEAF EXTRACTS
Journal Title: Journal of Biological and Scientific Opinion - Year 2015, Vol 3, Issue 6
Abstract
The objective of the study was aimed to investigate the anti-diabetic activity of Trichodesma indicum (L.) in both in vitro amylase assay and in vivo streptozotocin- nicotinamide induced type 2 diabetic rats.T. indicum leaves were extracted with four solvents Hexane, acetone, methanol and aqueous. They were tested for in vitro α amylase inhibitory activity and glucose uptake by yeast cells. The effect of four extracts at 200mg/kg and 400mg/kg is studied in normal and streptozotocin (STZ) – Nicotinamide induced type 2 diabetic rats.The results showed that methanolic leaf extract has moderate α –amylase inhibitory activity (IC50 value = 91.3 µg/ml) when compared to acarbose. Glucose uptake assay of four extracts showed significant activity. Methanolic extract showed effective inhibition (IC50 value = 46.72 µg/ml) of glucose uptake along with standard. The anti-diabetic activity of four extracts prominently reduces blood glucose levelsin STZ-nicotinamide induced diabetic rats. Methanol extract has shown estimable decrease of blood glucose level (P<0.01) along with glibenclamide. These findings suggest that anti-diabetic property of Trichodesma indicum (L.) methanol extract in type 2 diabetes mellitusis potential.
Authors and Affiliations
Narendra K , Satya Prasad, DSD Joshi, KVN Reddi, Swathi J , Sowjanya KM , Krishna Satya
Keywords
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- EP ID EP138380
- DOI 10.7897/2321-6328.03655
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