Anti-Diabetic and Anti-Obesity Effect of a Crude Polysaccharide Isolated from Vitexnegundo Linn. Leaves in db/db Mice
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 2
Abstract
Abstract:Various plant actives have been reported for their therapeutic potential in obesity so far and plant polysaccharides are one of them. Naturally occurring non-starch polysaccharides are widely known for their anti-oxidant, immunomodulatory, anti-diabetic and anticancer activities as well in various in vitro and in vivo test systems. This paper focuses on one such crude polysaccharide fraction isolated from the leaves of the plant Vitexnegundo which was tested for its anti-obesity activity in male db/db mice at 50 mg/Kg dose via both subcutaneous and per oral route of administration for 7 days. The activity via both the routes was compared with pair-fed and normal control animals for various parameters such as daily food intake, body weight, fasting serum glucose, insulin and triglyceride levels as well as changes in glucose levels during oral glucose tolerance test (OGTT). Obtained results demonstrate a significant reduction in food intake, body weight and fasting glucose levels in crude polysaccharide treated animals which are suggestive of its anti-obese activity. Further, a remarkable increase in fasting insulin and a significant decrease in glucose intolerance in crude polysaccharide treated animals was also observed, which indicate its anti-diabetic activity. Thus, this study primarily establishes a positive role of the crude polysaccharide from V. negundoleaves in treatment of both obesity and type 2 diabetes mellitus. Keywords:crude polysaccharide, Vitexnegundo, obesity, type 2 diabetes, db/db mice, inflammation, homeostatic model assessment (HOMA), area under the curve (AUC).
Authors and Affiliations
Dhwani Dave, Mustakim Mansuri, Gaurang Shah
Atypical Evolution of Squamous Cell Carcinoma of the Male Urethra: A Rare Case Report
Abstract:Squamous cell carcinoma of the male urethra is an exceptional tumor. All types tumors of the urethra representing less than 1% of urinary tract tumors. The prognosis remains unfavorable. We report the ninth case...
Comparative Study of Efficacy of Piperacillin/ Tazobactam and Cefoperazone/ Sulbactam Combinations in Hospitalised Patients of Complicated Urinary Tract Infections
Complicated UTIs (cUTIs) are one of the leading causes of the gram negative bacteraemia which occur in patients who have a functionally, metabolically, or anatomically abnormal urinary tract. The primary objective of thi...
Nonalcoholic Steatohepatitis with Significantly Elevated Levels of Carbohydrate Antigen 19-9
Abstract: Serum Carbohydrate antigen 19-9 (CA 19-9), a marker of malignant tumors, is generally slightly elevated in benign conditions. We report a 58 year old male with jaundice and elevated CA 19-9 levels (8,474 IU/ml)...
Phytochemical Screening, Acute (LD50) and Sub-Chronic Toxicity Studies of Aqueous Stem Bark Extract of CinnamomumVerum
Abstract:Cinnamon has a long history both as a spice and as a medicine. This study was carried out to screen the phytochemicals of the extract as well as to evaluate the acute (LD50) and sub-chronic toxicities of aqueous...
Serum Ghrelin and Adiponectin Level With Insulin Resistance Parameters in Obese Patients with Polycystic Ovary Syndrome Treated By Metformin
To evaluate the effect of metformin therapy for more than three months on serum ghrelin and adiponectin level and to assess the relationship between them with insulin resistance parameters in obese patients with polycyst...