ANTI-DIABETIC AND ANTI-OXIDANT PROPERTIES OF ALOE VERA IN ALLOXAN INDUCED DIABETIC RATS
Journal Title: International Journal of Pharmacognosy - Year 2016, Vol 3, Issue 7
Abstract
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Aloe vera (A. vera,Ghee-kuwar; family: Liliaceae) extract against alloxan induced diabetes in male adult Charles Foster rats to scientifically validate its use against diabetes. A. vera extract and standard drug (glibenclamide) prepared in aqueous gum acacia (2%, w/v) suspension and fed orally to alloxan induced diabetic ratsfor 30 days. Biochemical parameters in normal, diabetic control, standard (600µg/kg bw p.o.) and treated (1 g/kg bw p.o.) animals group were determined and compared. Treatment of alloxan induced diabetic rats with A. vera extract showed significant reduction (p<0.001) in blood glucose, lipid peroxide and significantly increased (p<0.001) Superoxide dismutase, Catalase and Protein. Furthermore, the extract (100-200 µg) when tested for its antioxidant activity in vitro, showed significant (p<0.001) inhibition in generation of super oxide anions and hydroxyl radicals. The results of the present study demonstrated anti-diabetic and anti-oxidant activities ofA. vera extract which could help in treatment of diabetes and related complications.
Authors and Affiliations
Prabha Verma et al.
Keywords
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