ANTI DIABETIC EFFECT OF MOMORDICA CHARANTIA (BITTER MELONE) ON ALLOXAN INDUCED DIABETIC RABBITS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 2
Abstract
Objective: to investigate the anti diabetic effect of the bitter melon on Alloxan induced diabetes in experimental animals (rabbits). Materials and Methods: the alcohol extract of whole fruit was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rabbit. The diabetic rabbits were divided into 5groups. Group I (control) received 2% gumacasia, groupie (positive control) received standard drug Metformin (62.5mg+2%GA), group III, IV, V (T1 T2 T3) were treated orally with a daily dose of 0.5(gm) 1gm, 1.5gm respectively for 35 days, for all diabetic rabbits after giving TEST,NC,PC preparations, the blood samples were collected and determined the blood glucose level 0,1,3,24hrs intervals. 0hr reading is before drug giving and remaining 3 readings after drugs giving. 24th her reading is considered as 0hr reading for the next day. Results: administration of alcohol of an extract of bitter melon produced a dose dependent decrease in blood glucose levels in Alloxan induced rabbits. There was a significant fall in blood sugar level in High dose (1.5GM/kg) in comparison to low dose (0.5gm/kg) and median dose (1gm/kg) shown by LSD test. This is comparable to the effect of Metformin. Conclusion: the results of this study show that chronic oral administration of an extract of Momordica charantia fruit at an appropriate dosage may be good alternative anti diabetic agent.
Authors and Affiliations
Yakaiah Vangoori| Assistant Professor and PG of Pharmacology, Santhiram Medical College, Nandyal, AP, India Corresponding author email: yakaiahpharma143@gmail.com, Mishra SS| Professor of Pharmacology, IMS & SUM Hospital, Bhubaneswar, Odisha, India, Ambudas B| Lecturer in Pharmacology, BLDEU’s Sri BM Patil Medical College Hospital & Research Centre, Bijapur, Karnataka, India, Ramesh P| PG of Pharmacology, Santhiram Medical College, Nandyal, AP, India, Meghavani G| PG of Pharmacology, Santhiram Medical College, Nandyal, AP, India, Deepika K| PG of Pharmacology, Santhiram Medical College, Nandyal, AP, India, Prathibha A| PG of Pharmacology, Santhiram Medical College, Nandyal, AP, India
Keywords
Related Articles
- EP ID EP10958
- DOI -
- Views 339
- Downloads 21
Assessing the Level of Development in Selected Cities in Razavi Khorasan province in Iran with an Approach to Health Indicators
Introduction: One of the major steps for policy and planning in the health sector and health services of the country, these services are informed of the status quo. This study aimed to assess the level of development of...
A STUDY TO ASSESS INJECTION PRACTICES IN CIVIL DISPENSARIES
Background: About 16 billion injections are administered each year worldwide, and at least half of them are unsafe. India contributes 25-30% of the global injection load. A majority of curative injections are unnecessar...
Oral Mycotic Flora and Its Association with pH, OHI-s & DMFT indexes in students of Mazandaran University of Medical Science in 2015
Candida fungi is grouped in the fermenting fungi strain. Candida types are usually the normal flora and mostly get pathogens in immune system deficiency. The most common place of candidiasis infection is in the mouth. O...
Speciation and antibiotic resistance pattern of Acinetobacter species in a tertiary care hospital in Uttarakhand
Acinetobacter species are Gram negative nonfermentative bacteria that have now emerged as important nosocomial pathogens involved in outbreaks of hospital infections.They are considered as opportunistic pathogens that r...
BACTERIOLOGICAL PROFILE OF WOUND INFECTION IN RURAL HOSPITAL IN R.R DISTRICT
Wound infection is a major problem in hospitals in developing countries. Wound infection causes morbidity and prolonged hospital stay thus the study was undertaken to know the bacteriological profile of wound infection...