Anti-Diabetic potential of herbal remedies on the glucose transport gene (GLUT) in liver and skeletal muscles
Journal Title: Journal of Research in Biology - Year 2015, Vol 5, Issue 8
Abstract
For a long time, several herbal medicines have been used for the treatment of diabetes in the form of compound drugs. Moreover, after the references made by researchers on diabetes mellitus, investigations on the hypoglycemic activity of compound drugs from medicinal plants have been more important. Although, the molecular mechanisms behind this effect is not much explored yet. There are various approaches to reduce the diabetes effect and its secondary complications, and herbal drugs are more preferred due to its less side effects and low cost. One of the major factors in the development of diabetes and its complications is the damage induced by free radicals. Therefore antidiabetic compounds with antioxidant properties would be more beneficial. It is hypothesized that the insulin mimetic effect, hypoglycemic effect and β-cell function of herbal remedies might add to glucose uptake through improvement in the expression of genes of the glucose transporter (GLUT) family in liver and skeletal muscles. Here we selected some plants with the ability to control blood glucose as well as to modulate some of the mechanisms involved in insulin resistance like β-cell function, glucose transport (GLUT) gene and incretin related pathways. Therefore, plants remedies may be appealing as an alternative and adjunctive treatment for diabetes mellitus
Authors and Affiliations
Waleed M. Al-Shaqha
Keywords
Related Articles
- EP ID EP567659
- DOI -
- Views 93
- Downloads 0
Drug resistance: a social perspective
Drug resistance is a defensive strategy developed by the microorganisms to evade the detrimental effects of antimicrobial agents. Over the years microorganisms have successfully counteracted the action of antimicrobials...
A new species of Agathoxylon Hartig from the Sriperumbudur formation, Tamil Nadu, India
Sriperumbudur Formation is one of the Upper Gondwana rock Formations found along the Palar basin, Tamil Nadu, India. The rock units found in this Formation are arenaceous and argillaceous, consists of green shales, clays...
Fly as pollinator in Caralluma umbellata Haw. (Asclepiadaceae) found in the Pachamalai hills, Eastern Ghats, Tamil Nadu
Pollination studies have been done in the Caralluma umbellata, a member of Asclepiadaceae found in the Pachamalai hills of Tamil Nadu. The hills lie between latitudes 11°09'00" to 11°27'00" N and longitudes 78°28'00" to...
Ichthyodiversity of the Rangavali Dam, Navapur, District Nandurbar, Maharashtra State
The study area was Rangavali dam of Navapur, district Nandurbar (Maharashtra State) India. This dam has not received much attention by limnologist and this prompted us to sample the fishes throughout the year to assess t...
Habitat preservation is a concern for conserving of Heliotropium rariflorum Stocks. in the forest of North Gujarat Region (NGR), Gujarat, India
The present study deals with the status, distribution and conservation of habitats of Heliotropium rariflorum – a threatened plant in the forest area of North Gujarat Region. It is tall under shrub; the distribution is e...