Anti-Diabetic Properties of The Methanolic Leaf Extract Of Bougainvillea Glabra On Alloxan-Induced Diabetic Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
The antidiabetic and antilipidemic effects of Bougainvillea glabra was investigated in this study using 25 male wistar rats. The rats were divided into 5 groups comprising of five animals each. These groups include Group I: Normal control (saline).Group II: Alloxan treated control (150 mg/kg.ip).Group III: Alloxan (150 mg/kg.ip) + Bougainvillea glabra. Whole plants extract (300 mg/kg, p.o),Group IV: Alloxan (150 mg/kg.ip) + Bougainvillea glabra. Whole plants extract (500mg/kg, p.o),Group V: Alloxan (150 mg/kg.ip) + Standard drug, Glibenclamide (5 mg/kg, p.o). The study lasted for three weeks although blood samples were obtained from the rat tails after every week. The results show that the extract significantly (p< 0.05) reduced the hyperglycaemia from 12±0.40 mmol/L (Diabetic Control) to 4.04±0.03 mmol/L (400 mg/kg group). Likewise, the extract significantly reduced the Total Cholesterol (TC), Triglyceride (TG) and Low-Density Lipoprotein Cholesterol (LDL-Cholesterol), while increasing the High-Density Lipoprotein Cholesterol (HDLC). In conclusion, the observations from this study show that Bougainvillea glabra has antidiabetic effect and beneficial effects on blood lipid profile, thus justifying the use of the plant by traditional medicine practitioners for the treatment of diabetes mellitus.
Authors and Affiliations
Dr. Sam Pavan Kumar G, Govardhan Reddy Kasireddy, Dr. Anil C, D. Sathish Kumar, Eppili Bhavani
Keywords
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