Anti-Diarrhoeal Activity of Ethanolic Leaf Extract of LuffaAcutangulaagainst Castor Oil Induced Diarrhoea in Rats
Journal Title: Scholars Academic Journal of Biosciences - Year 2017, Vol 5, Issue 11
Abstract
Diarrhea is a symptom marked by rapid and frequent passage of semisolid or liquid fecal material through the gastrointestinal tract and involves both an increase in the motility of the gastrointestinal tract along with increased secretions and a decrease in the absorption of fluid and thus loss of electrolytes particularly Na+ and water. Due to limitations associated with various treatments available, the need for developing newer drugs is imperative. This study aimed at investigating the anti-diarrheal activity of ethanolic leaf extract of Luffaacutangulaagainst castor oil induced diarrhoea.Loperamide 10mg.kg was used as reference control. Two dose levels (200 and 400mg/kg) of ethanolic leaf extract of Luffaacutangula were used to screen the efficacy of as antidiarrhoeal. The ethanolic leaf extract of Luffaacutangulaat 200 & 400mg/kg significantly (P<0.001) reduced the weight of wet stool and total weight of stool against castor oil induced diarrhoea. The effect produced by ethanolic leaf extract of Luffaacutangulawas comparable to that produced by the standard loperamide. In conclusion, the results obtained showed that ethanolic leaf extract of Luffaacutangulaexhibited antidiarrhoeal activity against castor oil induced diarrhoea in rats.
Authors and Affiliations
Asokan BR, Jaikumar S, Somasundaram G
Keywords
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