Anti-diarrhoeal potential of the aqueous root extract of Ziziphus abyssinica A. Rich.
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 5
Abstract
The aqueous root extract of Ziziphus abyssinica A. Rich. has been used in traditional medicine amongst Sokoto state indigenes in Northwest Nigeria for the treatment of diarrhoea. The study was conducted to evaluate the anti-diarrhoeal potential of this plant’s root and to justify its use in traditional medicine for the treatment of diarrhoea. The anti-diarrhoeal studies were evaluated (oral doses of 200, 400 and 600 mg/kg and Loperamide as the standard drug) using the castor oil-induced and the gastrointestinal motility models in Wistar rats. The result showed a significant (p<0.05) and dose dependent inhibitory activity against the castor oil-induced diarrhoea and reduction in gastrointestinal motility in charcoal meal test in rats. Based on the findings, the aqueous root extract of this plant may possess anti-diarrhoeal properties and validates its use in traditional medicine for the treatment of diarrhoea. Keywords: Ziziphus abyssinica, Anti-diarrhoea, Traditional medicine, Castor oil-induced model, Gastrointestinal motility model, Wistar rats
Authors and Affiliations
Chinenye J, Yusuf I. Alkali, Oguejiofor M. Ugwah, Kabiru Abubakar
Keywords
Related Articles
- EP ID EP378438
- DOI -
- Views 61
- Downloads 0
A review on Herbal Excipients and their pharmaceutical applications
The Herbal or natural excipients have a great advantage over their synthetic analogues as these are non-toxic, less expensive and freely available. The increasing awareness about these herbal excipients, which are manly...
Ethosomes: The Novel Drug Delivery Carriers
Abstract: Effective Delivery of bioactive molecules across the human skin has always been a challenge for formulation scientists because of the presence of the most impervious layer of skin, i.e. Stratum corneum. Various...
Prescription Pattern of Injection at Out Patient Pharmacy Department of Adama Hospital Medical College, Adama, Ethiopia
Abstract: Injection is an infusion method of putting drugs or fluids in to the body with a hollow needle and a syringe. The use of injection for treatment accompanied with variety of disadvantages including sepsis at adm...
Phyto Pharmacology and Ethnomedical Approach of Terminaliachebula (Kadukkaai): A Review
Traditional medicine can take part a significant task in achieving the goal of ‘Health for All’ and is offered to assisting the integration of traditional medicine with Western medicine all over the world (WHO). As a par...
Effect of topical anesthetics on pain during needle insertion of maxillary infiltration anesthesia: a systematic review and meta-analysis study
Abstract:Topical anesthetics are frequently used to reduce the pain of the needle insertion administration of topical anesthesia. The aim of this study is to evaluate the effect of topical anesthetics on pain during need...