ANTI-FERTILITY ACTIVITY OF WHOLE PLANT EXTRACT OF SARCOSTEMMA SECAMONE (L) BENNET ON MALE ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
Anti-fertility effect of ethanol extract of whole plant extract of Sarcostemma secamone was observed in male albino rats. The relative weight of the testes and epididymis were decreased. The epididymal sperm count, motility and sperm abnormality were reduced significantly in treated rats. There was an increase in serum protein, albumin, globulin, urea, creatinine and the activity of liver marker enzymes (SGOT, SGPT and ALP) levels of control and treated rats. The activities of serum antioxidants (CAT, SOD, GPx, GST and GRD) in plant extract treated rats were decreased. The results of the hormonal assay showed that increased serum levels of FSH and estrogen but decreased in the serum levels of LH and testosterone compared to control. The results of fertility test indicated that the treated adult male rats reduced the number of female’s impregnation. In addition, the number of implantations and the number of viable featuses were also decreased. The results of the present study concluded that, ethanol extract of whole plant of Sarcostemma secamone inhibited sperm concentration, motility and testosterone which might result in a male fertility.
Authors and Affiliations
Krishna S Thanga , G Sakthidevi , S Muthukumaraswamy , VR Mohan
Keywords
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