Anti-Ganglioside Q1b (GQ1b) Antibody Syndrome: A Case Series
Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 11
Abstract
Four patients were included in this case series. All tested positive for Anti-GQ1b antibody except one. All had external ophthalmoplegia, with associated clinical features. Case 1 presented with limb weakness, associated with external ophthalmoplegia, ataxia and areflexia, therefore diagnosed as a Guillain-Barre Syndrome (GBS) variant. Case 2 was diagnosed with Miller-Fischer Syndrome (MFS), due to external ophthalmoplegia, ataxia and areflexia. Case 3 was diagnosed with acute ophthalmoparesis and presented only with external ophthalmoplegia with negative Anti GQ1b-antibody. Case 4 was diagnosed with Bickerstaff’s Brainstem Encephalitis (BBE), presenting with external ophthalmoplegia, ataxia, hoarseness of voice and pyramidal signs. Case 1 and Case 4 were treated with intravenous immunoglobulin (IVIg) due to the severity of the disease, while Case 2 and Case 3 had spontaneous recovery. Those treated with IVIg resolved between 5 to 6 weeks, compared to those that recovered spontaneously within 2 to 5 months. Keywords: Anti-GQ1b antibody syndrome, Miller-Fischer Syndrome, Guillain-Barre Syndrome, Bickerstaff’s Brainstem Encephalitis, external ophthalmoplegia
Authors and Affiliations
Kenneth T Kenneth T, K. M. Chow, Lakana K. T, Wan Hazabbah W. H, Sangita Terumalay
Keywords
Related Articles
- EP ID EP379361
- DOI -
- Views 76
- Downloads 0
Oesophageal achalasia in an infant- A rare case report
Achalasia cardia is a neuromuscular disorder of the oesophagus, characterized by abnormal oesophageal motility and failure of lower esophageal sphincter relaxation. It usually manifests in the fourth and fifth decades of...
Penile Granular Hemangioma Treated With Intralesional Sclerotherapy
Hemangiomas are benign vascular lesions occurring in all parts of the body but are rarely found in the glans penis. Treatment options available for these lesions are sclerotherapy, cryotherapy, laser fulguration and surg...
Glass piece in the retina after road traffic accident: to remove or not to remove
A 7-month-old infant was brought to the Eye Clinic when his mother noticed peripheral cornea opacity 2 weeks after a road traffic accident. The accident involved a collision between two vehicles, and the windscreen of th...
Traumatic arteriovenous fistula: clinical aspects and surgery
Arteriovenous fistula is a direct communication between artery and vein, without transition to the capillaries. AVF is acute or could be chronic and diagnosis delayed years after the traumatism. Clinical findings are oft...
Heart as an Early Site of Metastasis from Squamous Cell Carcinoma of Occult Primary: Rare Case Report
Cardiac involvement by primary and secondary tumors is one of the least investigated subjects in oncology. Metastasis of squamous cell carcinoma (SCC) is rare and so is the bilateral ventricular involvement. We report a...