Anti-Ganglioside Q1b (GQ1b) Antibody Syndrome: A Case Series
Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 11
Abstract
Four patients were included in this case series. All tested positive for Anti-GQ1b antibody except one. All had external ophthalmoplegia, with associated clinical features. Case 1 presented with limb weakness, associated with external ophthalmoplegia, ataxia and areflexia, therefore diagnosed as a Guillain-Barre Syndrome (GBS) variant. Case 2 was diagnosed with Miller-Fischer Syndrome (MFS), due to external ophthalmoplegia, ataxia and areflexia. Case 3 was diagnosed with acute ophthalmoparesis and presented only with external ophthalmoplegia with negative Anti GQ1b-antibody. Case 4 was diagnosed with Bickerstaff’s Brainstem Encephalitis (BBE), presenting with external ophthalmoplegia, ataxia, hoarseness of voice and pyramidal signs. Case 1 and Case 4 were treated with intravenous immunoglobulin (IVIg) due to the severity of the disease, while Case 2 and Case 3 had spontaneous recovery. Those treated with IVIg resolved between 5 to 6 weeks, compared to those that recovered spontaneously within 2 to 5 months. Keywords: Anti-GQ1b antibody syndrome, Miller-Fischer Syndrome, Guillain-Barre Syndrome, Bickerstaff’s Brainstem Encephalitis, external ophthalmoplegia
Authors and Affiliations
Kenneth T Kenneth T, K. M. Chow, Lakana K. T, Wan Hazabbah W. H, Sangita Terumalay
Keywords
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