ANTI-HYPERCHOLESTEROLEMIC EFFECT OF ETHANOL FRUIT EXTRACT OF VANILLA (Vanilla planifolia Andrews) ON MALE MICE
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 9
Abstract
Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. Vanilla is one among plants that has cholesterol-lowering substances, but research on this subject is still lacking. This study aimed to determine whether ethanol fruit extract vanilla (Vanilla planifolia Andrews) can be used as anti-hypercholesterolemia in mice induced by quail egg suspension. Male mice (n=20) were divided into five groups. Group-1 (negative control) was given only high-fat quail egg yolks suspension. Group-2 (positive control) was treated with simvastatin at the dose of 10 mg/kg. Whereas group-3, 4 dan 5 were given vanilla extract of 50, 100, dan 200 mg/kg body weight respectively. The results showed that ethanol fruit extract of vanilla at the dose of 200 mg/kg significantly reduced level of blood cholesterol compared with that of negative control. It is worth concluding that vanilla fruit extract potential to be used as anti-hypercholesterolemia.
Authors and Affiliations
Rina Maryani
Keywords
Related Articles
- EP ID EP671786
- DOI -
- Views 165
- Downloads 0
DETECTION OF GLUTATHINE S-TRANSFRASE M1 AND GLUTATHINE S-TRANSFRASE T1 NULL POLYMORPHISM AMONG SUDANESE PATIENT WITH SICKLE CELL ANAEMIA
Background: Glutathione S-transferase (GST) enzymes that play a key role in detoxification of activated carcinogens are shown to be one of the potential modifiers of individualized risk for several cancer types. Objectiv...
EVALUATION OF THE ANTIOXIDANT, ANTIMICROBIAL, CYTOTOXIC AND GENOTOXIC ACTIVITIES OF THE AQUEOUS EXTRACT OF CHALICES OF HIBISCUS SABDARIFFA LINN
Hibiscus sabdariffa L., which belongs to the family Malvaceae, is an important medicinal plant, originally from India, Sudan and Malaysia and popularly known in Brazil like “vinagreira”, “azedinha”, “quiabo azedo”, “caru...
DESIGN PRIMER GENE TET(M) LACTOBACILLUS PLANTARUM
Tetracycline is an antibiotic that reported have resistance to some infectious bacteria. One of the mechanisms of tetracycline antibiotic resistance is the ribosomal protection through the tet(M) gene. The tet(M) gene ha...
ASSESSMENT OF THE EFFECT OF AGE AND PARITY ON CATAMENIA AND MENSTRUAL CYCLE IN WOMEN IN OBIO/AKPOR LOCAL GOVERNMENT AREA OF RIVERS STATE, NIGERIA.
Catamenia, also called menstrual bleeding, refers to the shedding of the uterine endometrium. It is characterized by a bleed from the uterus through the vagina. This research aimed at investigating the effect of parity o...
OYSTER MUSHRROM CULTIVATION AT DIFFERENT PRODUCTION SYSTEMS: A REVIEW
This paper aims to review historical perspectives, nutritional and medicinal benefits, biodiversity, cultivation, diseases and their control, pathogen detection systems, food safety concerns and use of spent mushroom com...