ANTI HYPERGLYCEMIC EVALUATION OF TERMINALIA CHEBULA LEAVES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 11
Abstract
Objective: The antihyperglycaemic potentiality of Terminalia chebula leaves has not yet been investigated thoroughly compared to its fruit counterpart. Therefore, the purpose of this study was to assess the hypoglycaemic potentiality of Terminalia chebula Retz leaves both in vitro and in vivo. Methods: Fresh leaves of T. chebula were collected, authenticated and grounded to a fine powder. The powdered material was extracted in methanol. The hypoglycaemic potentiality of the extract was accessed in vitro using enzyme alpha-amylase and alpha-glucosidase. The antihyperglycaemic activity of the methanol extract active fraction was accessed in vitro and in vivo. The active fraction thus obtained was partially characterized using Fourier transform infrared spectroscopy (FTIR) and High-performance liquid chromatography (HPLC) analysis. Results: The crude leave methanol extract of Terminalia chebula demonstrated 100% α glucosidase inhibition with IC50–0.956±0.342 mg/ml compared to standard drug acarbose. Oral administration of the active fraction to diabetic rats loaded with maltose significantly (P<0.05) retarded the postprandial spike of blood glucose level compared to standard drug acarbose. Partial characterization of the fraction reveals the presence of hydrosoluble tannin gallic acid. Conclusion: The study provides an in vitro and in vivo rationale evidence of Terminalia chebula leaves to retard postprandial hyperglycemia.
Authors and Affiliations
Jayashree Dutta, Mohan Chandra Kalita
Keywords
Related Articles
- EP ID EP566112
- DOI 10.22159/ijpps.2018v10i11.28167
- Views 72
- Downloads 0
PHYSICOCHEMICAL, PHYTOCHEMICALS AND ANTIOXIDANT EVALUATION OF GUAZUMA ULMIFOLIA FRUIT
Objective: The present study was designed to evaluate the physicochemical, qualitative, quantitative analysis and antioxidant activity of ethanol fruit extract of Guazuma ulmifolia. Studies were carried out to detect the...
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF HYDROALCOHOLIC EXTRACTS FROM ALOYSIA POLYSTACHYA GRISEB MOLDENKE AND LIPPIA TURBINATA GRISEB (VERBENACEAE)
Objective: The aims of this study were to determine polyphenols and flavonoids composition, to evaluate the antioxidant and antibacterial activities and possible antibacterial synergistic effects of hydroalcoholic extrac...
AN ORAL FEED STRATEGY IN SHEEP FOR IMPROVED DIGESTIBILITY, NUTRIENT UTILIZATION AND METHANE MITIGATION
Objective: A trial was conducted to study the efficacy of herbal formulation Ruchamax (M/S Ayurvet Limited, India) on digestibility and nutrient utilization in Deccani sheep.Methods: 12 growing healthy Deccani sheep (5-6...
HESPERIDIN HYDROGEL FORMULATION USING PECTIN-CHITOSAN POLYMER COMBINATION
Objective: Hesperidin is flavonoid glycosides that proven to have therapeutic activity to any desease, one of them is colon disease; but, its low solubility (< 100 mg/L) makes small absosption inside the body so it ne...
IN VITRO ANTIPLASMODIAL ACTIVITYOF ETHANOL EXTRACTS OF BORNEO MEDICINAL PLANTS (HYDROLEASPINOSA, AMPELOCISSUSRUBIGINOSA, URARIA CRINITE, ANGIOPTERISEVECTA)
Objective: The efforts to obtain new antimalarial medicine were among others to explore and to develop both natural substances and synthetic compounds whose activities have been established. An in vitro antiplasmodial ac...