Anti-Inflammatory Activity Of Oxycarotenoid Extracts Isolated From Coriander Leaves And Curry Leaves On Formalin Induced Chronic Inflammation Rat Model
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 7
Abstract
Carotenoids are found in abundance in green leafy vegetables. Carotenoids help in photosynthesis by absorbing light energy in plants. They also have an important antioxidant function of deactivating free radicals. Carotenoids are of two types - carotenes and oxycarotenoids. Oxycarotenoids are the carotenoids which contain one or more oxygen atoms such as lutein, zeaxanthin, cryptoxanthin, etc. The present study evaluates the anti-inflammatory activity oxycarotenoids isolated from the coriander leaves and curry leaves. The anti-inflammatory activity was determined using formalin induced chronic paw oedema model. The oxy- carotenoids extracted from coriander leaves administered at a dose of 40mg/kg body weight showed an inhibition of 44.76% and 61% on 3rd day and 7th day after formalin injection whereas the oxycarotenoids extracted from curry leaves showed an inhibition of 59.05% and 63.77% on 3rd day and 7th day after formalin injection. The results are comparable with that of indomethacin standard administered group which showed an inhibition of 60% and 65.04%. These findings suggest that the oxycarotenoids isolated from leafy vegetables (coriander leaves and curry leaves) have significant anti-inflammatory properties.
Authors and Affiliations
Anusha A. M.
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