Anti-inflammatory and analgesic activity of methanolic bark extracts of Zanthoxylum Armatum
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 10
Abstract
A comprehensive study on the phytochemical contents and biological activities of different extracts from bark of Zanthoxylum armatum was studied. The extracts of the bark parts contained various levels of phenols, flavonoids and saponins. Present research work mainly focus on analgesic and antiinflammatory efficacy of methanolic bark extract of Zanthoxylum armatum belongs to the family Rutaceae. The analgesic activity was tested in albino mice by giving oral doses of 100, 200 and 300 mg/kg body weight using tail immersion method, acetic acid induced writhing and formalin induced analgesic effect. The outcome of the analgesic activity showed significant and dose dependent analgesic effect (P<0.001). The brink was found to be 60 min after treatment with 100, 200, and 300 mg/kg of the methanolic root extract. The activity produced by the extract was significantly lower than the standard drug used (Diclofenac sodium). The dose of the standard drug used is 100 mg/kg. The results clearly states that methanolic extracts showed delayed response towards thermally induced pain, decreased acetic-acid induced writhing and also showed significant inhibition in both the phases of formalin induced pain test. The analgesic activity of the extracts can be attributed to their central and peripherally mediated secondary messengers in the management of pain. The phytochemical constituents present in the bark extract may contribute for the analgesic activity. The results finally support the herbal remedies over the conventional dosages in the management of pain.
Authors and Affiliations
Arun Satyadev Siddhanadham
Keywords
Related Articles
- EP ID EP331153
- DOI -
- Views 81
- Downloads 0
In vitro antioxidant potential of secondary and tertiary growth forms of Salvinia molesta Mitchell
The aquatic weed Salvinia molesta causes adverse ecological disruptions leading to considerable social, ecological and economic damages. It reduces dissolved oxygen content, blocks sunlight reaching the other aquatic spe...
Antioxidant and antimicrobial activities of Salix babylonica extracts
The methanolic extracts of the leaves and bark of Salix babylonica and their petroleum ether, methylene chloride and ethyl acetate fractions were investigated for their antioxidant and antimicrobial activities. They were...
Cytotoxicity and apoptosis of glioblastoma multiforme cell line by arginine deiminase purified from a higher productive isolation Enterococcus faecium M1
Purified arginine deiminase from Enterococcus faecium M1 isolate is the strongest cancer treatment enzyme due to its activity and stability in different environmental conditions. The cytotoxicity of ADI to glioblastoma m...
Development and validation of a HPTLC method for simultaneous estimation of efavirenz and lamivudine in pharmaceutical formulations
A simple, sensitive and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of efavirenz and lamivudine in pharmaceutical formulations. The chromatogr...
The image of temple’s priestess in the poetry of “Silver Age”
The article regards images of priestesses of the temple in the works of Bryusov and Hlebnikov. As an example the poems of Bryusov “Aganat”. Phoenician story and “In the, Bela temple”, and Hlebnikov’s “Dark, black daughte...