Anti-inflammatory and Antifibrotic Effects of Plant Regulatory Peptides in Patients with Steatohepatitis and Cirrhosis: Opportunities of Primary Liver Cancer Prevention
Journal Title: Journal of Regenerative Biology and Medicine - Year 2019, Vol 1, Issue 2
Abstract
The pathogenesis of steatohepatitis, which develops on the background of non-alcoholic fatty liver disease and may be the cause of liver cirrhosis, is considered in the article. Also, the paper focuses on the prospects of using peptide drugs for the treatment of liver cirrhosis. The study found that the preparation of plant regulatory peptides GA-40 has pronounced hepatoprotective, anti-inflammatory and anti-fibrotic effects, which is confirmed by the elastometry data of the shear wave. The results of this work indicate that the use of the drug GA-40 was accompanied not only by the normalization of the inflammatory panel of the liver and triglycerides, but also by a likely decrease in the level of glypican-3 - the main factor that causes the development of primary liver cancer. Gene protector and immunocorrector GA-40, harmonizing metabolic processes in the liver, as well as suppressing inflammation and preventing excessive output of hepatocytes in apoptosis, has a positive effect on the prognosis of the disease. Reduced expression of glypican-3 in patients in the study group indicates that GA-40 is able to control the level of pro-oncogenic trigger proteins, thus reducing the risk of primary liver cancer.
Authors and Affiliations
Anatolyy Pechinka¹, Levan Kakliani², Zurab Gogitidze³, Sergii Konovalenko4*and Iryna Miroshnychenko5
Keywords
Related Articles
- EP ID EP707312
- DOI https://doi.org/10.37191/Mapsci-2582-385X-1(2)-009
- Views 77
- Downloads 0
Alice in Wonderland Syndrome: An Update of Present Data with a Special View to Body Position, Traumatic and Genetic Aspects
Alice in Wonderland Syndrome (AIWS) was named after the description of Lewis Carroll in his novel. In 1955, John Todd, a psychiatrist described this entity for the first time and results in a distortion of perception. To...
ACE-2-Receptors of the Epidermis, Dermal Vascular Walls and Sebaceous Gland Cells: The Way of COVID-19 Entry into the Body?
Since the outbreak near a fish market in Wuhan, China, in December 2019, researchers have been searching for an effective therapy to control the spreading of the new coronavirus SARS-CoV-2 and inhibit COVID-19 infection....
In Continuously Battling COVID-19 with Innovative Perspectives
In the commentary to a paper issued in J Chem Edu Res Prac 2020, 4(2), 1-4 by Laila Mahmoud Montaser2020 entitled “Could putting the mesenchymal stem cells technology into practice be an optimistic therapy for the critic...
Safety Study of AAV hTERT and KLOTHO gene transfer therapy for dementia
A sponsored, interventional, non-randomized study without a control group using a novel and proprietary central nervous system gene transfer method to deliver AAV hTert and Klotho genes to five patients with mild or mode...
Neural Stem Cells to Glial Cells an Important factor for Brain Injury
Stem cells have the capacity to differentiate into any type of cell or organ. Stems cell originate from any part of the body, including the brain. Brain cells or rather neural stem cells have the capacitive advantage of...