Anti-inflammatory and Hepatoprotective Potentials of Methanol Leaf Extract of Arachis hypogea
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 16, Issue 6
Abstract
The anti-inflammatory and hepatoprotective properties of methanol extract of Arachis hypogea leaves were studied. At 400 mg/kg, the extract significantly suppressed the development of hind paw oedema induced by egg albumin, which compares favorably with a standard anti–inflammatory drug aspirin (acetylsalicylate) which at 100 mg/kg inhibits egg-albumin induced rat paw oedema. It was observed that the extract significantly inhibited platelet aggregation in a dose dependent fashion. At 0.6 and 0.7 mg/ml the percentage inhibition of platelet aggregation was observed to be 53.13 and 68.75% which compare closely to the standard drug indomethacin at 0.2 and 0.4 mg/ml which was found to be 53.13 and 65.63% respectively. Similarly, there was also an observable decrease in the activity of prostaglandin synthase which was dosage dependent at 0.1, 0.5 and 1 mg/ml, the percentage enzyme activity was 65, 70 and 95% respectively. Also, at 1 and 4 mg/ml of indomethacin, the percentage enzyme activity was 94.75 and 99.25% respectively. There was non-significant difference (P<0.05) in the selected liver function parameters assayed in all the groups after 21 days of administration. The study shows that the extract may contain anti-inflammatory agents with hepatoprotective properties and may yet serve as template for the development of more synthetic anti-inflammatory agents of clinical significance.
Authors and Affiliations
R. C. Ibeh, G. S. Aloh, G. C Ikechukwu, S. O. Ebhohon, U. I. Edward, C. J. Njoku, F. O. Azubike-Izah, E. U. Ejiofor, C. I. Nwankwo, C. E. Oriaku
Keywords
Related Articles
- EP ID EP313048
- DOI 10.9734/BJPR/2017/33210
- Views 87
- Downloads 0
Effect of Resveratrol on Some Haematological Parameters of Lead-intoxicated Male Wistar Rats
The aim of this experiment was to investigate the effect of resveratrol on haematological parameters of lead-induced toxicity in male wistar rats. The study employed 36 male wistar rats (150 - 250 g) divided equally into...
Dose Response of Viola odorata on Meiotic and Mitotic Chromosomes of Vicia faba
Aims: Viola odorata is a medicinally important plant. It contains bioactive principle viz violin and probably methyl salicylic ester. The present study was designed to analyze the effect of different doses of this medici...
Antibacterial Screening of Some Synthesized Palmitoyl Amino Acids and Their Aromatic Analogues
Aims: The aims of the research were to synthesize, characterize some palmitoyl amino acids and their aromatic analogues and to screen the synthesized compounds for possible antibacterial activity Study Design: Synthesis...
Are Depot Anti-psychotics Associated with Longer Persistence in Treatment Compared with Oral Antipsychotics among Patients with Schizophrenia?
Aim: Non-adherence with antipsychotics is associated with poor outcomes in patients with schizophrenia. It was anticipated that drop-out from treatment due to non-compliance with oral anti-psychotics could be abated with...
Angiogenesis and Antioxidant Activity of in vitro and in vivo Tuber of Ceropegia pusilla Wight and Arn
Background: Angiogenesis refers to the formation of new blood vessels. This biological process lays an important role in embryonic development. Ceropegia pusilla (Asclepiadaceae) used in folk medicine system to treat var...