ANTI-INFLAMMATORY EFFECT OF LIPID EXTRACT OF SEA PEN (VIRGULARIA GUSTAVIANA) IN MICE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: Sea pens are a highly specialized group of anthozoa coelenterates. Sea pens were collected by wading at low tide in intertidal zone fromBandar Abbas Costal.Method: Sea pens were identified by classification keys, and samples were sending to the academic center of California for admission. Comparingidentification keys genus from virgularidaes family was identified, it consisted of Virgularia gustaviana. To find an effective fraction, the inflammatoryeffect of lipid extract hexane of sea pen V. gustaviana was evaluated. In this study, lipid percentages of V. gustaviana were measured, and the percentageof sterol profile was assessed. To assess inflammation, mouse ear edema method was used. Male NMRI mice were categorized into three groupsincluding positive control (dexamethasone 15 mg/kg), negative control (saline) and experimental one with dose of 10, 20, 40, and 60 mg/kg of lipidextracted of chloroform and hexane as a separate group.Results: Total lipid V. gustaviana was 21.96% and sterol profile which was 5680.31 mg/kg contains cholesterol 1910.38 mg/kg that equal 57.95%of total sterol and brassicasterol, campesterol, campestanol, stigmasterol, beta-sitosterol were measured. Fatty acid profile was measured by gaschromatography-mass and heptadecane 44.25%, beta.-Bisabolene ss Cyclohexene’1, 18.16%, and methyl arachidonate 54.17% was assessed.Statistical analysis was performed that anti-inflammatory effect of all doses of 40-10 mg/kg is significant to the control.Conclusion: Chloroform and hexane extracts of sea pen has a strong anti-inflammatory effects even at low doses which is probably due to 54%arachidonic acid in the compounds.Keywords: Anti-inflammatory activities, Lipid extract, Sea pen (Virgularia gustaviana).
Authors and Affiliations
Sharareh Sharifi, Shila Safaeian
Keywords
Related Articles
- EP ID EP605656
- DOI -
- Views 86
- Downloads 0
EVALUATION OF PHARMACOLOGICAL STABILITY OF PERILLA OIL AND PERILLA OIL CAPSULE
Objective: The present study explained the effect of storage conditions on the stability (total phenolic content (TPC), acid and peroxide values, and antioxidant capacity) of free perilla oil (PO) and capsulated PO (POC)...
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING REVERSE-PHASE HIGHPERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF POTENTIAL DEGRADATION PRODUCTS OF REGADENOSON FROM ITS PARENTERAL DOSAGE FORM
Objective: The objective was to develop and validate the stability indicating reverse-phase high-performance liquid chromatography method for the quantification of potential degradation products of regadenoson (REGA) fro...
SPLIT-HALF TABLETS: A COMPLETE REVIEW FOR ANALYTICAL TESTING
A solid oral dosage form (as a tablet) which is an immediate or extended-release dosage form which necessitates the scoring bisect of the tablet. This review discusses the quality attributes and interpretations for the s...
A NOVEL SPECTROPHOTOMETRIC DETERMINATION OF METHYLDOPA THROUGH TERNARY COMPLEXATION PROCEDURE USING FE(III), MN(II), AND CO(II) WITH 2-AMINOPYRIDINE
Objective: The present study is aimed to find a three simple, low cost, accurate, rapid, and sensitive spectrophotometric methods based on the formation of ternary complexes to assay methyldopa (MTD) in both pure and pha...
CARDIOPROTECTIVE EFFECTS OF ETHANOLIC LEAF EXTRACT OF IPOMOEA BATATAS ON DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS
 Objective: This study was aimed to investigate the protective effects of ethanolic leaf extract of Ipomoea batatas (EEIB) on doxorubicin (DOX)induced cardiotoxicity using Albino Wistar rats by monitoring the enzymatic,...