Anti-Mullerian Hormone: An Indicator for the Severity of Polycystic Ovarian Syndrome
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 8
Abstract
<strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a common endocrinopathy that accompanied with long term complications. <em>Purpose </em>Features of PCOS including sonographic aspects, androgens, luteinizing hormone (LH) and lutenizing and follicular stimulating hormones ratio LH/FSH ratio as well as Anti-Mullerian Hormone (AMH) were evaluated according to their diagnostic potency in detecting different degrees of PCOS severity.<br /> <strong>Objective: </strong>The aim of this study to assess the possible role of AMH as the diagnostic marker for different degrees of PCOS.<br /> <strong>Materials and Methods: </strong>In this cross-sectional study, a total of 150 women aged 18–46 years Patients were consecutively included as they presented in our clinic. 50 patients were diagnosed with sever PCOS (based on Rotterdam criteria consensus), 50 patients were diagnosed with mild PCOS, and 50 women served as controls. In day 2-4 of cycle, transvaginal sonography was performed and serum hormonal level of AMH, LH, FSH, testosterone. PCOS patients fulfilling all Rotterdam criteria were defined as having severe PCOS (<em>n </em>= 50), while patients showing oligo-/amenorrhoea and polycystic ovaries but without hyperandrogenemia were defined as having mild PCOS (<em>n </em>=50). And control group (n= 50). All patients were treated at the University Hospital of El-Hussein, Al-azhar university and at Ain Shams General Hospital Cairo Egypt.<br /> <strong>Results:</strong> The strongest group difference between controls and severe PCOS patients was observed for AMH showing an age-adjusted odds ratio of 2.56 [95 % confidence interval (CI) 2.00–3.27; <em>p </em>< 0.0001]. Age-adjusted receiver operating characteristic analysis showed that the area under the curve (AUC) of 0.88 (95 % CI: 0.80–0.95) for AMH and 0.94 (95 % CI 0.88–0.98) for antral follicle count did not differ significantly in their ability to discriminate between severe PCOS patients and controls. AMH showed higher AUC estimates than androgens, ovarian volume, LH and LH/FSH ratio and an AUC of 0.80 (95 % CI: 0.65–0.91) for detecting mild PCOS.<br /> <strong>Conclusions:</strong> this study comparing the diagnostic potency of AMH, sonographic aspects, androgens and LH/FSH ratio according to different PCOS subgroups while accounting for the age-dependency of AMH. In cases where vaginal scans are not feasible or in patients without hyperandrogenemia AMH may be used as a surrogate parameter in PCOS diagnosis, superior to androgens and gonadotropins.<br />
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP583655
- DOI 10.12816/0044636
- Views 112
- Downloads 0
An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency
Background: Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency is the most common enzyme deficiency globally and is more remarkable in certain parts of the world which had high malaria prevalence in the past. It is an X...
Causes of Absenteeism Rate among Staff Nurses at Medina Maternity and Child Hospital
<strong>Background:</strong> Multiple factors are associated with absenteeism among nursing staff around the world with an increasing rate that affects the delivery of health care to patients and reflects non-satisfactio...
Clinical comparative study between Magnesium sulphate versus Rocuronium versus Dexmedetomidine as adjuvants for local anesthetic in peribulbar block for eye surgeries
Background: Regional anesthesia is a preferred technique for ophthalmic surgery. It is safe, inexpensive and provides efficient ocular anesthesia for ophthalmic surgery. It is associated with less hemodynamic instability...
Knowledge, Behaviors, and Attitudes about Noise-induced Hearing Loss among Adults in Albaha Region: A Cross-sectional Study
Background: Worldwide, more than one billion people are affected by hearing loss. Noise-induced hearing loss (NIHL) is reported among the most prevalent occupational diseases. However, little is known about the current l...
A Two-Week Nitazoxanide-Based Quadruple Treatment as a Rescue Therapy for Helicobacter Pylori Eradication
<strong>Introduction: </strong>Helicobacter pylori is the most common prevalent chronic human bacterial infection estimated in 50% of the global population but only induces clinical diseases in 10-20% of infected individ...