Anti-mullerian hormone as a diagnostic marker in women with polycystic ovary syndrome
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2016, Vol 3, Issue 4
Abstract
Plasma levels of AMH in women serves as an important biomarker of ovarian reserves and indicates the small follicular growth. The reproductive span in healthy women is predicted by progressive age related decline of plasma AMH levels. The values are low in the clinical condition of diminished ovarian reserve, indicating the presence of few remaining follicles within the ovary. Recent studies have also shown the importance of this hormone in various pathological conditions of ovary including PCOS. In women with PCOS, the small ovarian antral follicles increase and AMH secreted by these developing follicles can be used as an important marker to detect follicular impairment. It is suggested that the increased secretion of LH and/or testosterone may have a positive effect on the secretion of AMH by the ovarian follicles. A positive correlation has also been found between high AMH levels and androgen over-production due to intrinsic defects of thecal cells. In conclusion, high AMH levels have been predicted as a response to various treatments of PCOS, while improvement in various clinical and biochemical parameters have been associated with decline in AMH, thus supporting a very important role of AMH in diagnosis and treatment of PCOS.
Authors and Affiliations
Iram Shabir, Sheikh Ishaq, Arif Akbar Bhat, Roohi Ashra, Sabhiya Majid
Keywords
Related Articles
- EP ID EP241815
- DOI -
- Views 80
- Downloads 0
Trends of hysterectomy in the rural tertiary level teaching hospitals in Northern India
Objective: The aim of this study is to analyze indications, type and complications of hysterectomies done in the two rural tertiary level teaching institutes in Northern India. Materials and Methods: It was a retrospecti...
Impact of gestational diabetes mellitus on maternal & fetal outcome
Background: Women with GDM are at increased risk for adverse obstetric and perinatal outcome. Hence, it is imperative that an early detection and management of the disease is done to ensure better maternal and fetal outc...
Effect of communication skills training for obtaining written Informed consent: an Indian experience
Objectives: The primary objective of the study was to evaluate whether formal communications skills training improves the quality of written informed consent. The secondary objective was to evaluate the patient satisfact...
Assessment of determinants of polycystic ovarian syndrome in women in reproductive age group attending tertiary healthcare facility in southern Maharashtra
Introduction Pathophysiology of PCOS reveals excessive ovarian andor adrenal androgen secretion results in hyperandrogenism and is associated clinical manifestations ranging from hirsutism acne malepattern baldness to ir...
Scenario of obstetrical emergencies at a tertiary care hospital
Objective: To study relative preponderance of critical obstetrical emergencies with various maternal factor like quality of antenatal care during pregnancy, regular antenatal checkup during pregnancy, socioeconomic statu...