ANTI-MUTAGENICEFFECT OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 8
Abstract
Aim of The Study: The present study was designed to evaluate the anti-mutagenic potential of Methanolic extract of Dalbergia latifolia, using micronucleus (MN) assay in mice bone marrow. Materials and methods: The anti-mutagenic effect of Dalbergia latifolia was assessed using cyclophosphamide MN formation in mice. The animals were pre-treated with the Methanolic extract of Dalbergia latifolia orally at two doses of 100, 200mg/kg body weight for seven days. In MN test the two doses provided protection when given 24hrs prior to a single i.p administration of cyclophosphamide (100 mg/kg body weight). These results demonstrate that Methanolic extract of Dalbergia latifolia has got anti-mutagenic potential. Results: Percentage Micronucleus Polychromatic erythrocytes (%MN PCE) formation signicantly increased (P<0.001) after 24hrs. Of Cyclophosphamide treatment when compared to normal mice. Conclusion: The study shows that a signicant decrease in mitotic index of cyclophosphamide treated animals, which can be due to the affected cell division in the bone marrow (Gonzalves et al., 2008). Methanolic extract of Dalbergia latifolia signicantly inhibited the disturbances in the cell division of mouse bone marrow and therefore it showed anti-mutagenicity in micronucleus tests
Authors and Affiliations
Mr. Chandrajeet Kumar Yadav, Pinky Yadav, Arjun Saraf
Keywords
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